Radiation hybrid map of the domestic
cat and human RH comparative map. Ideograms for each cat chromosome are shown
to the left of each map. Hybridization results from human on cat chromosome
painting are depicted to the left of each ideogram for comparison to the RH-derived
syntenies. The extent of RH-based physical coverage of each chromosome is not
implied except where indicated by cytogenetic localization of Type I markers
on the RH map. Orientation of RH maps relative to the chromosome is established
except for the following chromosomes: D1, E3, F1 and Y. Green arrows indicate
the inferred position of the centromere on the RH map, as determined by maximum
retention frequency-based centromeric effects and syntenic
boundaries. Loci labeled in red were ordered at odds >1000:1, those
in blue >100:1, those in black <100:1. The distances on the cat
RH map are represented by alternating black and red vertical bars, with each
bar corresponding to 50 cR5000. The length of each feline RH linkage group is
listed below each map. The human RH maps are shown on the right. RH coordinates
for the outermost markers of each human conserved homology block are listed.
Human loci positioned on the Stanford G3-based RH map are depicted by a bar
spanning the range of the same map interval in the Genebridge4-based RH.
Human ESTs which have not been associated with a named gene of known function
are listed by their UniGene cluster identifier. Feline homologues of these loci
are indicated by the prefix Fc. preceding the human cluster identifier number.
The majority of feline microsatellites are denoted by the prefix FCA or an F,
followed by a number. Dashed lines connect homologous Type I loci in both cat
and human RH maps. Gaps in the RH maps of B3 and E1 are connected by dashed
lines (no distance implied) and are bracketed by linked microsatellite loci
in the genetic linkage map.
