Biography:

Dr. Smith obtained his Ph.D. degree from the Department of Biology of the Johns Hopkins University working in the field of population genetics in 1989 and completed post-doctoral training in molecular evolution at the University of California, San Diego in 1991. Subsequently, he joined the Salk Institute for Biological Studies where he became the Assistant Director of the Human Genome Center that focused on human chromosome 11. While at the Salk Institute he developed genomic sequence sampling (now a division of Genbank) . Dr. Smith has worked for the operational and technical support contractor (currently SAIC-Frederick ) at the National Cancer Institute at Frederick since 1994 on HIV-1/AIDS host genetics, a novel gene identification technique (Mapping by Admixture Linkage Disequilibrium), using genes as biomarkers in epidemiological studies of syringe sharing behavior and on other research topics.

Research:

MALD - is a theoretically powerful, but as yet unproven approach to association gene mapping that tracks long range haplotypes generated by gene flow among recently admixed ethnic groups such as African Americans and Hispanics. (Read more…which will be linked to a page with more details)

Publications:

Zhang L, Kao WH, Berthier-Schaad Y, Liu Y, Plantinga L, Jaar BG, Fink N, Powe N, Klag MJ, Smith MW, Coresh J . Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. J. Am. Soc. Nephrol. 17: 2285-92, 2006. [Online Journal]

Chretie JP, Coresh J, Berthier-Schaad Y, Kao WH, Fink N, Klag MJ, Marcovina SM, Giaculli F, Smith MW . Three single-nucleotide polymorphisms in LPA account for the majority of lipoprotein(A) level elevation in African Americans compared to European Americans. J Med Genet . 2006. [Online Journal]

Liu Y, Berthier-Schaad Y, Fallin MD, Fink NE, Tracy RP, Klag MJ, Smith MW, Coresh J . IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort. J. Am. Soc. Nephrol. 17: 863-70, 2006. [Online Journal]

Shrestha S, Smith M, Broman K, Farzadegan H, Vlahov D, Strathdee S. Multiperson Use of Syringes Among Injection Drug Users in a Needle Exchange Program. JAIDS . 2006. In Press . [Journal]

Lind J, Hutcheson-Dilks H, Williams S, Moore J, Essex M, Ruiz-Pesini E, Wallace D, Tishkoff S, O'Brien S, Smith M. Elevated male European and female African contributions to the genomes of African American individuals. Human Genetics . 2006. In Press . [Journal]

Smith MW, O'Brien SJ . Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet . 6: 623-32, 2005. [Journal]

Laud K, Marian C, Avril MF, Barrois M, Chompret A, Goldstein AM, Tucker MA, Clark PA, Peters G, Chaudru V, Demenais F, Spatz A, Smith MW, Lenoir GM, Bressac-de Paillerets B, French Hereditary Melanoma Study Group . Comprehensive analysis of cdkn2a (p16ink4a /p14arf) and cdkn2b genes in 53 melanoma index cases considered to be at heightened risk of melanoma. J Med Genet . 2005. [Journal]

Shrestha S, Strathdee SA, Broman KW, Smith MW . Unknown biological mixtures evaluation using STR analytical quantification. Electrophoresis . (2):409-15, 2005. [Journal]

Shrestha S, Strathdee SA, Galai N, Oleksyk T, Fallin MD, Mehta S, Schaid D, Vlahov D, O'Brien SJ, Smith MW . Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. Journal of Infectious Diseases . (1):16-26, 2005. [Journal]

Liu Y, Berthier-Schaad Y, Fink NE, Fallin MD, Tracy RP, Klag MJ, Smith MW, Coresh J . Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. Am J Kidney Dis . 46: 78-85, 2005. [Journal]

 

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