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PubMed
List of Publications by E.O. Freed
Selected Publications
Joshi, A.,
Munshi, U., Ablan, S.D., Nagashima, K., and Freed, E.O. (2008)
Functional replacement of a retroviral late domain by ubiquitin fusion.
Traffic, in press (Sept 10 Epub ahead of print). [Abstract] [Full-text
PDF
article - 796KB] Greene,
W.C., Debyser, Z., Ikeda, Y., Freed, E.O., Stephens, E., Yonemoto, W.,
Buckheit, R., Este, J., and Cihlar, T. (2008) Novel targets for HIV
therapy. Antiviral Res., in press (Sept 11 Epub ahead of print). [Abstract] [Full-text
PDF
article - 1128KB] Waheed,
A.A., Ono, A., and Freed, E.O. (2008) Methods for the study
of HIV-1 assembly. In HIV Protocols, 2nd Ed., Humana Press, in
press. Waheed,
A.A., Ablan, S.D., Soheilian, F., Nagashima, K., Ono, A., Schaffner, C.P., and
Freed, E.O. (2008) Inhibition of human immunodeficiency virus
type 1 assembly and release by the cholesterol-binding compound amphotericin B
methyl ester: Evidence for Vpu dependence. J. Virol. 82: 9776-9781. [Abstract] [Full-text
PDF
article - 624KB]
Saad, J.S., Ablan, S.D., Ghanam, R.H., Kim, A., Andrews, K., Nagashima, K., Soheilian,
F., Freed, E.O., and Summers, M.F. (2008) Structure of the
myristylated human immunodeficiency virus type 2 matrix protein and the role of
phosphatidylinositol-(4,5)-bisphosphate in membrane targeting. J. Mol. Biol.
382: 434-447.
[Abstract] [Full-text
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article - 3510KB] Liu,
F., Stephen, A.G., Waheed, A.A., Aman, M.J., Freed, E.O., Fisher, R.J.,
and Burke, T.R., Jr. (2008) SAR by oxime-containing peptide libraries:
Application to Tsg101 ligand optimization. ChemBioChem 9: 2000-2004.
[Abstract] [Full-text
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article - 313KB] Adamson,
C.S., and Freed, E.O. (2008) Recent progress in antiretrovirals
– lessons from resistance. Drug Discov. Today 13: 424-432.
[Abstract] [Full-text
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article - 627KB)]
Joshi, A., Garg, H., Nagashima, K., Bonifacino, J.S., and Freed, E.O.
(2008) GGA and Arf proteins modulate retrovirus assembly and release.
Mol. Cell 30: 227-238.
[Abstract] [Full-text
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article - 1606KB]
Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, A.A., Tong, X., Hong, A., Heck,
S., Curreli, F., Goger, M., Cowburn, D., Freed, E.O., and Debnath, A.K.
(2008) A cell-penetrating helical peptide as a potential HIV-1 inhibitor.
J. Mol. Biol. 378: 565-580.
[Abstract] [Full-text
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article - 1062KB] Gousset,
K., Ablan, S.D., Coren, L.V., Ono, A., Soheilian, F., Nagashima, K., Ott, D.E.,
and Freed, E.O. (2008) Real-time visualization of HIV-1 Gag
trafficking in infected macrophages. PLoS Pathog. 4: e1000015.
[Abstract] [Full-text
PDF
article - 667KB] Viard,
M., Ablan, S.D., Zhou, M., Veenstra, T.D., Freed, E.O., Raviv, Y., and
Blumenthal, R. (2008) Photoinduced reactivity of the HIV-1 envelope
glycoprotein with a membrane-embedded probe reveals insertion of portions of the
HIV-1 gp41 cytoplasmic tail into the viral membrane. Biochemistry 47: 1977-1983.
[Abstract] [Full-text
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article - 227KB] Luttge,
B.G., Shehu-Xhilaga, M., Demirov, D.G., Adamson, C.S., Soheilian, F., Nagashima,
K., Stephen, A.G., Fisher, R.J., and Freed, E.O.. (2008) Molecular
characterization of feline immunodeficiency virus budding. J. Virol. 82:
2106-2109.
[Abstract] [Full-text
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article - 2408KB] Fujii,
K., Hurley, J.H., and Freed, E.O. (2007) Beyond Tsg101: The
role of Alix in 'ESCRTing' HIV-1. Nat. Rev. Microbiol. 5: 912-916.
[Abstract] [Full-text
PDF
article - 2408KB] Joshi,
A., and Freed, E.O. (2007) HIV-1 Gag trafficking. Future
HIV Ther. 1: 427-438.
[Abstract] [Full-text
PDF
article - 936KB] Waheed,
A.A., and Freed, E.O. (2007) Influenza virus not cRAFTy enough
to dodge viperin. Cell Host Microbe 2: 71-72. [Abstract] [Full-text
PDF
article - 229KB] Adamson,
C.S., and Freed, E.O. (2007) Human immunodeficiency virus
type 1 assembly, release, and maturation. In Jeang, K.-T.
(ed.), HIV-1: Molecular Biogenesis and Pathogenesis: Viral Mechanisms, 2nd Ed.,
Advances in Pharmacology, Vol. 55, Elsevier Inc. pp. 347-387. [PubMed
citation] Garg,
H., Joshi, A., Freed, E.O., and Blumenthal, R. (2007) Site-specific
mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander
apoptosis and fusion/hemifusion. J. Biol. Chem. 282: 16899-16906.
[Abstract] [Full-text
PDF
article - 657KB] Waheed,
A.A., Ablan, S.D., Roser, J.D., Sowder, R.C., Schaffner, C.P., Chertova, E., and
Freed, E.O. (2007) HIV-1 escape from the entry-inhibiting effects
of a cholesterol-binding compound via cleavage of gp41 by the viral protease.
Proc. Natl. Acad. Sci. USA 104: 8467-8471. [Abstract] [Full-text
PDF
article - 675KB]
Lee, S., Joshi, A., Nagashima, K., Freed, E.O., and Hurley, J.H.
(2007) Structural basis for viral late-domain binding to Alix. Nat.
Struct. Mol. Biol. 14: 194-199.
[Abstract] [Full-text
PDF
article - 631KB] Ono,
A., Waheed, A.A., and Freed, E.O. (2007) Depletion of cellular
cholesterol inhibits membrane binding and higher-order multimerization of human
immunodeficiency virus type 1 Gag. Virology 360: 27-35. [Abstract] [Full-text
PDF
article - 490KB] Freed,
E.O., and Martin, M.A. (2007) HIVs and their replication.
Chapter 57. In Knipe, D.M., and Howley, P.M. (eds.), Fields Virology,
5th Ed., Lippincott, Williams, and Wilkins: Philadelphia. pp. 2107-2186.
Munshi,
U.M., Kim, J., Nagashima, K., Hurley, J.H., and Freed, E.O. (2007)
An Alix fragment potently inhibits HIV-1 budding: Characterization of binding
to retroviral YPXL late domains. J. Biol. Chem. 282: 3847-3855.
[Abstract] [Full-text
PDF
article - 492KB] Saad,
J.S., Loeliger, E., Luncsford, P., Liriano, M., Tai, J., Kim, A., Miller, J.,
Joshi, A., Freed, E.O., and Summers, M.F. (2007) Point mutations
in the HIV-1 matrix protein turn off the myristyl switch. J. Mol. Biol.
366: 574-585.
[Abstract] [Full-text
PDF
article - 1814KB] Tang,
S., Ablan, S., Dueck, M., Ayala-López, W., Soto, B., Caplan, M., Nagashima, K.,
Hewlett, I.K., Freed, E.O., and Levin, J.G. (2007) A second-site
suppressor significantly improves the defective phenotype imposed by mutation
of an aromatic residue in the N-terminal domain of the HIV-1 capsid protein.
Virology 359: 105-115.
[Abstract] [Full-text
PDF
article - 1613KB] Freed,
E.O., and Mouland, A.O. (2006) Meeting Review: The cell biology
of HIV-1 and other retroviruses. Retrovirology 3: 77-87.
[Abstract]
[Full-text PDF
article - 444KB] Li,
F., Zoumplis, D., Matallana, C., Kilgore, N.R., Reddick, M., Yunus, A.S., Adamson,
C.S., Salzwedel, K., Martin, D.E., Allaway, G.P., Freed, E.O., and Wild,
C.T. (2006) Determinants of activity of the HIV-1 maturation inhibitor
PA-457. Virology 356: 217-224. [Abstract] [Full-text
PDF
article - 571KB] Adamson,
C.S., Ablan, S.D., Boeras, I., Goila-Gaur, R., Soheilian, F., Nagashima, K., Li,
F., Salzwedel, K., Sakalian, M., Wild, C.T., and Freed, E.O. (2006)
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor
PA-457 (bevirimat). J. Virol. 80: 10957-10971. [Abstract] [Full-text
PDF
article - 1326KB] Liu,
F., Stephen, A.G., Adamson, C.S., Gousset, K., Aman, M.J., Freed, E.O.,
Fisher, R.J., and Burke, T.R., Jr. (2006) Hydrazone- and hydrazide-containing
N-substituted glycines as peptoid surrogates for expedited library synthesis:
Application to the preparation of Tsg101-directed HIV-1 budding antagonists.
Org. Lett. 8: 5165-5168.
[Abstract] [Full-text
PDF
article - 127KB] Waheed,
A.A., Ablan, S.D., Mankowski, M.K., Cummins, J.E., Ptak, R.G., Schaffner, C.P.,
and Freed, E.O. (2006) Inhibition of HIV-1 replication by amphotericin
B methyl ester: Selection for resistant variants. J. Biol. Chem. 281: 28699-28711.
[Abstract] [Full-text
PDF
article - 779KB] Joshi,
A., Nagashima, K., and Freed, E.O. (2006) Mutation of dileucine-like
motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly,
Gag-Gag interactions, Gag-membrane binding, and virion maturation. J. Virol.
80: 7939-7951.
[Abstract] [Full-text
PDF
article - 725KB] Freed,
E.O. (2006) HIV-1 Gag: Flipped out for PI(4,5)P2.
Proc. Natl. Acad. Sci. USA 103: 11101-11102. [PubMed
citation] [Full-text PDF
article - 224KB] Davis,
M.R., Jiang, J., Zhou, J., Freed, E.O., and Aiken, C. (2006)
A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes
the interaction of the envelope protein subunits gp120 and gp41. J. Virol.
80: 2405-2417.
[Abstract] [Full-text
PDF
article - 591KB] Fu,
W., Dang, Q., Nagashima, K., Freed, E.O., Pathak, V.K., and Hu, W.-S.
(2006) Effects of Gag mutation and processing on retroviral dimeric RNA
maturation. J. Virol. 80: 1242-1249. [Abstract] [Full-text
PDF
article - 367KB] Ono,
A., Waheed, A.A., Joshi, A., and Freed, E.O. (2005) Association
of human immunodeficiency virus type 1 Gag with membrane does not require highly
basic sequences in the nucleocapsid: Use of a novel Gag multimerization assay.
J. Virol. 79: 14131-14140. [Abstract] [Full-text
PDF
article - 337KB] Ono,
A., and Freed, E.O. (2005) Role of lipid rafts in virus replication.
Adv. Virus Res. 64: 311-358. [PubMed
citation] Sklar,
P.A., Masur, H., Grubb, J.R., Voell, J., Witek, J., Ono, A., Freed, E.O.,
and Maldarelli, F. (2005) Pravastin does not have a consistent antiviral
effect in chronically HIV-infected individuals on antiretroviral therapy.
AIDS 19: 1109-1111.
[PubMed
citation] [Full-text PDF
article - 75KB] Demirov,
D.G., and Freed, E.O. (2004) Retrovirus budding. In
Mechanisms of Enveloped Virus Release (E.O. Freed, ed.), Virus Research, Vol.
106, pp. 87-102.
[Abstract] [Full-text
PDF
article - 441KB] Freed,
E.O. (2004) Preface. In Mechanisms of Enveloped
Virus Release (E.O. Freed, ed.), Virus Research, Vol. 106, pp. 85-86.
[PubMed
citation] [Full-text PDF
article - 31KB] Ono,
A., Ablan, S.D., Lockett, S.J., Nagashima, K., and Freed, E.O. (2004)
Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma
membrane. Proc. Natl. Acad. Sci. USA 101: 14889-14894.
[Abstract] [Full-text
PDF
article - 886KB] Freed,
E.O., and Ross, S.R. (2004) Retroviruses 2004: Review of the 2004
Cold Spring Harbor Retroviruses conference. Retrovirology 1: 25 (E-pub).
[Abstract] [Full-text
PDF
article - 227KB] Svarovskaia,
E.S., Xu, H., Mbisa, J.L., Barr, R., Gorelick, R.J., Ono, A., Freed, E.O.,
Hu, W.-S., and Pathak, V.K. (2004) Human apolipoprotein B mRNA-editing
enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions
through interactions with viral and nonviral RNAs. J. Biol. Chem. 279: 35822-35828.
[Abstract] [Full-text
PDF
article - 356KB] Freed,
E.O. (2004) HIV-1 and the host cell: An intimate association.
Trends Microbiol. 12: 170-177. [Abstract] [Full-text
PDF
article - 237KB] Ono,
A., and Freed, E.O. (2004) Cell-type-dependent targeting of
human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular
body. J. Virol. 78: 1552-1563.
[Abstract] [Full-text
PDF
article - 4759KB] Murakami,
T., Ablan, S., Freed, E.O., and Tanaka, Y. (2004) Regulation
of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease
activity. J. Virol. 78: 1026-1031.
[Abstract] [Full-text
PDF
article - 266KB] Shehu-Xhilaga,
M., Ablan, S., Demirov, D.G., Chen, C., Montelaro, R.C., and Freed, E.O.
(2004) Late domain-dependent inhibition of equine infectious anemia virus
budding. J. Virol. 78: 724-732. [Abstract] [Full-text
PDF
article - 928KB] Tang,
S., Murakami, T., Cheng, N., Stephen, A.C., Freed, E.O., and Levin, J.G.
(2003) Human immunodeficiency virus type 1 N-terminal capsid mutants containing
cores with abnormally high levels of capsid protein and virtually no reverse transcriptase.
J. Virol. 77: 12592-12602. [Abstract] [Full-text
PDF
article - 1064KB] Li,
F., Goila-Gaur, R., Salzwedel, K., Kilgore, N.R., Reddick, M., Matallana, C.,
Castillo, A., Zoumplis, D., Martin, D.E., Orenstein, J.M., Allaway, G.P., Freed,
E.O., and Wild, C.T. (2003) PA-457: A potent HIV inhibitor that
disrupts core condensation by targeting a late step in Gag processing. Proc.
Natl. Acad. Sci. USA 100: 13555-13560.
[Abstract] [Full-text
PDF
article - 383KB] Goila-Gaur,
R., Demirov, D.G., Orenstein, J.M, Ono, A., and Freed, E.O. (2003)
Defects in human immunodeficiency virus budding and endosomal sorting induced
by TSG101 overexpression. J. Virol. 77: 6507-6519.
[PubMed
citation] [Full-text PDF
article - 3180KB] Freed,
E.O. (2003) The HIV-TSG101 interface: Recent advances in a budding
field. Trends Microbiol. 11: 56-59. [Abstract]
Freed,
E.O. (2002) Viral late domains. J. Virol. 76: 4679-4687.
[PubMed
citation] [Full-text PDF
article - 726KB] Freed,
E.O. (2002) Rafting with Ebola. Science 296: 279.
[PubMed
citation] [Full-text PDF
article - 54KB] Demirov,
D.G., Orenstein, J.M., and Freed, E.O. (2002) The late domain
of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent
manner. J. Virol. 76: 105-117. [Abstract] [Full-text
PDF
article - 1800KB] Demirov,
D.G., Ono, A., Orenstein, J.M., and Freed, E.O. (2002) Overexpression
of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain
function. Proc. Natl. Acad. Sci. USA 99: 955-960.
[Abstract] [Full-text
PDF
article - 400KB] Freed,
E.O., and Martin, M.A. (2001) HIVs and their replication.
In Knipe, D.M., and Howley, P.M. (eds.), Fields Virology, Chapter 59,
4th Ed., Lippincott, Williams, and Wilkins: Philadelphia, pp. 1971-2041.
Ono, A.,
and Freed, E.O. (2001) Plasma membrane rafts play a critical
role in HIV-1 assembly and release. Proc. Natl. Acad. Sci. USA 98: 13925-13930.
[Abstract] [Full-text
PDF
article - 353KB] Ono,
A., Demirov, D., and Freed, E.O. (2000) Relationship between
human immunodeficiency virus type 1 Gag multimerization and membrane binding.
J. Virol. 74: 5142-5150. [Abstract] [Full-text
PDF
article - 1524KB] Murakami,
T., and Freed, E.O. (2000) Genetic evidence for an interaction
between human immunodeficiency virus type 1 matrix and alpha-helix 2 of the gp41
cytoplasmic tail. J. Virol. 74: 3548-3554. [Abstract] [Full-text
PDF
article - 530KB] Ono,
A., Orenstein, J.M., and Freed, E.O. (2000) Role of the Gag
matrix domain in targeting human immunodeficiency virus type 1 assembly.
J. Virol. 74: 2855-2866.
[Abstract] [Full-text
PDF
article - 4484KB] Murakami,
T., and Freed, E.O. (2000) The long cytoplasmic tail of gp41
is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation
into virions. Proc. Natl. Acad. Sci. USA 97: 343-348.
[Abstract] [Full-text
PDF
article - 225KB]
Last
modified: 2 October 2008 |
