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Head,
Viral Mutation Section
HIV Drug Resistance Program
Center for Cancer Research
National Cancer Institute
P.O. Box B, Building 535
Frederick, MD 21702-1201
Phone: 301-846-1710
Fax:
301-846-6013
E-mail: pathakv@mail.nih.gov
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Dr. Vinay K. Pathak received his B.A. in Biology from the University of California,
Los Angeles, in 1979. He obtained his M.S. in Comparative Pathology in 1983
from the University of California, Davis, for characterization of mouse mammary
tumor virus proviral integration sites near the int1 and int2
loci in mammary tumors and hyperplastic tissues in Dr. Robert Cardiff's laboratory.
He received his Ph.D. for work on characterization of the eukaryotic protein synthesis
initiation factors eIF-2a
and eIF-2b
in Dr. John W.B. Hershey's laboratory at the University of California, Davis,
in 1988. He was a postdoctoral fellow under the guidance of Dr. Howard Temin
from 1988 to 1991, where he determined the in vivo forward mutation rate
of spleen necrosis virus and characterized the nature of mutations that arise
during retroviral replication. These studies were the first to report G-to-A hypermutation in a retrovirus, now known to be the result of cytidine deamination by host restriction APOBEC3 proteins. In 1991, Dr. Pathak became an Assistant Professor in the Department of Biochemistry and the Mary Babb Randolph Cancer Center at West Virginia University. He was promoted to Associate Professor with tenure in 1998. He joined the National Cancer Institute in 1999 as Senior Investigator and Head of the Viral Mutation Section in the HIV Drug Resistance Program. Dr. Pathak was appointed as Guest Editor for the "HIV Drug Resistance" special issue of Viruses, published in 2010. In 2012, he received the NIH Asian and Pacific Islander American Organization Award for outstanding accomplishments in biomedical research.
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