Fuller, R.W., Bokesch, H.R., Gustafson, K.R., McKee, T.C., Cardellina, J.H., II, McMahon, J.B., Cragg, G.M., Soejarto, D.D., Boyd, M.R. BioMed. Chem. Lett. 4: 1961-1964, 1994.
Abstract:
In an effort to identify an adequate and sustainable natural source of the recently described anti-HIV drug development candidate calanolide A, we undertook chemical and biological studies of the latex exuded from trees of the genus Calophyllum. Although we found that calanolide A was not present in latex from the original source species, C. lanigerum var. austrocoriaceum, we did observe that a related coumarin, costatolide, was abundant in latex of C. teysmannii var. inophylloide. Costatolide is currently being evaluated as a possible alternative to calanolide A for drug development.
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