Kirk R. Gustafson, Linda K. Walton, Raymond C. Sowder, II, Donald G. Johnson, Lewis K. Pannell, John H. Cardellina, II, and Michael R. Boyd:J.Nat.Prod., 63(2): 176-178, 2000.
Abstract:
Four new macrocyclic polypeptides were isolated and identified from an extract of the tropical tree Chassalia parvifolia. Circulins C-F are 29-30 amino acid cyclic peptides in which the entire primary amino acid chain is covalently cyclized via peptide bonds. Their structures were deduced from a combination of FABMS analyses, N-terminal Edman degradation, endoproteinase digestion, and amino acid analyses. All the peptides share a high degree of sequence homology and contain six cysteine residues forming three intramolecular disulfide bridges. Circulins C-F inhibited the cytopathic effects of in vitro HIV-1 infection with EC50 values of 50-275 nM.
Circulin C
Circulin D
Circulin E
Circulin F
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