Pellynol I, a new cytotoxic polyacetylene from the sponge Pellina sp.

Nat.Prod.Lett., in press, 2000.

Rashid,M.A.; Gustafson,K.R.; Boyd,M.R.

Abstract:

Bioassay-guided fractionation of an organic extract of a South African collection of the sponge Pellina sp. afforded six polyacetylenic metabolites. These were identified as pellynols A-D, pellynol F, and a new compound, pellynol I (1). The structure of 1 was elucidated by NMR and MS analyses and by comparison of its spectral data with related compounds. The six pellynols all exhibited cytotoxic activity against human tumor cell lines.

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