Michael T. Davies-Coleman, Charles. L. Cantrell, Kirk R. Gustafson, John A. Beutler, Lewis K. Pannell, and Michael R. Boyd: J.Nat.Prod. 63: 1411-1413, (2000).
Abstract:
Two new 3,6-epidioxy-7,10-tetrahydrofurano C26 unsaturated fatty acids, stolonic acids A (1) and B (2), were isolated from a previously undescribed ascidian species, Stolonica sp. collected off the Maldive Islands in the Indian Ocean. The structures and relative stereochemistry of 1 and 2 were determined using conventional spectroscopic methods. Both compounds exhibited antiproliferative activity against selected human melanoma and ovarian tumor cell lines, with IC50 values of approximately 0.05-0.1 g/mL.
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