Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin A, a new antitumor macrolide lactam from the sponge Poecillastra species

Rashid, M.A., Gustafson, K.R., Crouch, R.N., Groweiss, A., Pannell, L.K., Van, Q.N. and Boyd, M.R.: Org. Lett. 4: 3293-3296, 2002.

Abstract:

Poecillastrin A (1), a new polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge Poecillastra species. The structure of poecillastrin A (1) was assigned using NMR data acquired at 500 MHz with an inverse-detection cryogenic probe and at 800 MHz with a room-temperature probe.

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