Dennis J. Milanowski, Kirk R. Gustafson, James A. Kelley, and James B. McMahon: J.Nat.Prod. 67: 70-73, 2004.
Abstract:
An extract of the marine bryozoan Caulibugula intermis, collected in the Indo-Pacific off Palau, produced a distinct pattern of differential cytotoxicity in the National Cancer Institute's 60 cell line antitumor screen. Bioactivity-directed fractionation of the extract provided six new compounds, caulibugulones A-F (1-6). The structures of these novel metabolites were determined by spectrochemical analyses including LC-MS, HRFABMS, 1-D and 2-D NMR experiments, and by comparison with related compounds. The structures of compounds 2 and 3 were confirmed by chemical interconversion. The isolated compounds exhibited IC50's of 0.03-1.67 µg/mL against murine tumor cells in an in vitro cytotoxicity assay.
Up to MTDP References
Up to MTDP Home Page