New nitrogenous constituents from the South African marine ascidian Pseudodistoma sp.

Rashid,M.A.; Gustafson,K.R.; Cartner,L.K.; Pannell,L.K.; Boyd,M.R.: Tetrahedron 57: 5751-5755 (2001).

Abstract:

Cytotoxicity-guided fractionation of an extract of the South African marine ascidian Pseudodistoma sp. provided pseudodistamine (1), a new bis alkyl amine, two new aliphatic amines 2 and 3, and a new ß-carboline alkaloid 4. The structures of compounds 1-4 were elucidated by spectroscopic methods and by comparison with spectral data from structurally related compounds. The absolute stereochemistry of 1 was assigned by Mosher's ester analyses, while the stereochemistry of 2 and 3 was established by degradation and derivatization studies. Compound 2 demonstrated cytotoxic activity against four different human tumor cell lines, with an IC50 of approximately 6.0 µg/mL.

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