Dai, J.R., Decosterd, L.A., Gustafson, K.R., Cardellina, J.H., II, Gray, G.N., Boyd, M.R.J. Nat. Prod. 57: 1511-1516, 1994.
Abstract:
During the reisolation of the trimeric naphthoquinone derivative conocurvone (1) from an extract of the Australian shrub Conospermum incurvum, six monomeric naphthoquinones were isolated. These include three novel 1,4-naphthoquinone derivatives: 3-methyl-14,15-dihydro-15- hydroxyteretifolione B (3), 3-methyl-14,15-dihydro-15-hydroxyteretifolione B methyl ether (4), and 2,3-dimethyl-6-hydroxy-7-methoxy-1,4-naphthoquinone (5). In addition, the previously reported compounds 3-methylteretifolione B (6), 3-methylteretifolione B methyl ether (7), and 8-geranyl-2,7- dihydroxy-3-methyl-1,4-naphthoquinones were elucidated by spectral methods. While conocurvone (1) is a potent inhibitor of HIV-1-induced cell killing, all of the monomeric naphthoquinone derivatives were inactive against HIV-1.
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