Molecular Targets Development Program

Collaborative Research Opportunities

Display Technologies

"Display Technologies" refers to an increasingly broad array of biology-driven approaches to the generation of chemical diversity, in lieu of or in complement to, purely chemical-based approaches (e.g., combinatorial chemistry). Display technologies in general provide a means to generate libraries of modularly coded biomolecules (e.g., peptides, proteins, antibodies) that can be screened for desired properties. Display technologies can be utilized for ligand discovery against a desired molecular target, for identifying or characterizing the known and/or unknown molecular target(s) of a given compound, for optimization of desired properties of a given biomolecule (e.g., protein or peptide), and other applications. A classical example of a display technology is phage-display, which is widely used for generating and screening peptide ligands and antibodies. Numerous other display and related technologies are now available or are evolving to complement the classical display methods. This evolution will further facilitate molecular targets validation, drug discovery research and development. The MTDP invites CCR, NCI investigators to consider collaborations to explore applications of display technologies, and related biological approaches to generating chemical diversity, for the discovery, characterization and validation of novel molecular targets, and to the elucidation of molecularly targeted ligands, bioprobes and leads for drug discovery research initiatives of the CCR, NCI.

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Last modified November 14, 2005