Molecular Targets Development Program

Project Proposal Seminars: 2000-2005

Date	Investigator(s)	Title	Project Manager(s)
December 18, 2000	Philipp Kaldis	Cyclin Dependent Kinases as Potential Screening Targets	Barry O'Keefe
August 8, 2001	Chem Akin Diana Linnekin	Mastocytosis: The Disease, Therapeutic Challenges and Potential Opportunities	Kirk Gustafson
December 7, 2001	Gordon Hager	The Dynamics of Nuclear Receptor Induced Chromatin Remodeling and Gene Activation	John Beutler, Angie Dull
May 1, 2002	Stuart LeGrice	A High Throughput Screen for HIV-1 RNase H Inhibitors	John Beutler
September 9, 2002	Sam Hwang	Chemokine Receptors in Cancer Metastasis	Roberta Gardella
January 22, 2003	Ji Ming Wang	Formylpeptide Receptors as Potential Targets for Drug Development	Tawnya McKee
January 28, 2003	Chou-Chi Li	Involvement of p97-VCP as a Molecular Chaperone in the Ubiquitin- Proteasome Pathway Mediated Activities	Tawnya McKee
February 12, 2003	Keith Robertson	Inhibition of DNA Methyltransferases as a Novel Strategy for Cancer Treatment	John Beutler
February 19, 2003	Michael Dean	The Role of the ABC Transporter ABCG2/MXR in Multidrug Resistance	Kirk Gustafson, Heidi Bokesch
March 10, 2003	Marston Linehan	Potential Molecular Targets and Cancer of the Kidney	Tawnya McKee
March 14, 2003	Suresh Arya	Lentiviral Gene Transfer: Search for "Drugs" to Target Transcriptional and Post-transcriptional Apparatus	TBD
March 18, 2003	Victor Lobanenkov	BORIS - A Novel Testis- Specific Paralogue of CICF-Maps to a Cancer Associated Chromosome 20q13 Gain-Amplification Region, Shows Aberrantly Activated Expression in Many Types of Malignancies, and Transforms Cells in Culture	Kirk Gustafson, Heidi Bokesch
April 23, 2003	Daniel McVicar	The Killer Ig-like Receptors (KIR) and Triggering Receptors Expressed on Myeloid Cells (TREM) as Potential Targets for the Treatment of Infectious Disease and Cancer	Tawnya McKee
May 9, 2003	Laura Schmidt	Functional Studies of the Birt-Hogg-Dube Protein, Folliculin, Through Identification of Interacting Proteins	Toshi Mori
July 29, 2003	Nancy Colburn	Discovery of a Drug that Mimics the Targeting Specificity of Dominant Negative AP-1	Henrich
January 8, 2004	Shyam Sharan	Functional Dissection of Human Breast Cancer Susceptibility Genes	TBD
February 19, 2004	David Gius	Thioredoxin as a molecular target
April 15, 2004	Thomas Sayers	Death receptor - mediated apoptosis and cancer therapy	Bokesch
April 19, 2004	Peter Johnson Esta Sterneck	Transcription factor C/EBPbeta: an effector of Ras-induced tumorigenesis and a potential target for pharmacological inhibition	TBD
July 7, 2004	Peter Aplan	SCL Gene Activation Leads to T-Cell Acute Lymphoblastic Leukemia in Mice and Men	TBD
September 21, 2004	Allan Weissman	A novel E2 binding site and a Cue domain are critical to the ERAF ubiquitin ligase (E3) function of gp78, the tumor autocrine motility factor receptor	Beutler
March 16, 2005	Andrew Hurwitz	Identifying novel antigens on a subset of T lymphocytes, regulatory T cells or 'Tregs'
July 12, 2005	Donald Bottaro	Signal Transduction by Hepatocyte Factor	TBD
September 16, 2005	David Salomon	Cripto 1: An Oncofetal Gene as a Therapeutic Target in Cancer	Henrich
December 7, 2005	Kyung S. Lee	The polo-box domain of Polo-like kinase 1 as a potential therapeutic target	Kurian

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Last modified December 7, 2005

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