NIH Logo
Navigation bar for Alex Compton's pages on HIV Dynamics and Replication Program websiteAlex Compton's home page on HIV Dynamics and Replication ProgramAlex Compton's research page on HIV Dynamics and Replication Program websiteAlex Compton's publications page on HIV Dynamics and Replication Program websiteAlex Compton's staff page on HIV Dynamics and Replication Program website
... Skip navigation links
Link to home page of HIV Dynamics and Replication Program website
Link to Mission, HIV Dynamics and Replication Program, National Cancer Institute
Link to News & Events, HIV Dynamics and Replication Program, National Cancer Institute
Link to Research Team, HIV Dynamics and Replication Program, National Cancer Institute
Link to Clinical Trials, HIV Dynamics and Replication Program, National Cancer Institute
Link to Recruitment, HIV Dynamics and Replication Program, National Cancer Institute
Link to Resources, HIV Dynamics and Replication Program, National Cancer Institute
Link to Related Sites, HIV Dynamics and Replication Program, National Cancer Institute
Link to Staff Directory, HIV Dynamics and Replication Program, National Cancer Institute

Link to National Cancer Institute - external website
Link to National Cancer Institute at Frederick - external website
...

Publications


PubMed summary

Google Scholar profile

ORCID ID 0000-0002-7508-4953


Selected Key Publications

Shi, G., Ozog, S., Torbett, B.E., and Compton, A.A. (2018) mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Proc. Natl. Acad. Sci. USA 115: E10069-E10078. Abstract     Full-text PDF     PMID 30301809; PMCID PMC6205447
DOI 10.1073/pnas.1811892115

Compton, A.A., Roy, N., Porrot, F., Billet, A., Casartelli, N., Yount, J., Liang, C., and Schwartz, O. (2016) Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity. EMBO Rep. 17: 1657-1671.
Abstract     Full-text PDF     PMID 27601221; PMCID PMC5090704
DOI 10.15252/embr.201642771

Cover     About the cover

Compton, A.A., Bruel, T., Porrot, F., Mallet, A., Sachse, M., Euvrard, M., Liang, C., Casartelli, N., and Schwartz, O. (2014) IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe 16: 736-747.
Abstract     Full-text PDF     Supplemental information     PMID 25464829
DOI 10.1016/j.chom.2014.11.001

Related article: Fassati, A. (2014) Commentary: Fuse me IFITM can! Retrovirology 11: 104.

Compton, A.A., and Emerman, M. (2013) Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses. PLoS Pathog. 9(1): e1003135.
Abstract     Full-text PDF     Supporting information     PMID 23359341; PMCID PMC3554591
DOI 10.1371/journal.ppat.1003135

Featured in PLoS Collections: Immunobiology
Featured paper on This Week in Virology (TWiV) episode 237: Paleovirology

Compton, A.A., Hirsch, V.M., and Emerman, M. (2012) The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict. Cell Host Microbe 11: 91-98. Abstract     Full-text PDF     Supplemental information
PMID 22264516; PMCID PMC3266539     DOI 10.1016/j.chom.2011.11.010


Recent Publications

Shi, G., Ozog, S., Torbett, B.E., and Compton, A.A. (2018) mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Proc. Natl. Acad. Sci. USA 115: E10069-E10078. Abstract     Full-text PDF     PMID 30301809; PMCID PMC6205447
DOI 10.1073/pnas.1811892115

Shi, G., Schwartz, O., and Compton, A.A. (2017) More than meets the I: The diverse antiviral and cellular functions of interferon-induced transmembrane proteins. Retrovirology 14: 53.
Abstract     Full-text PDF     PMID 29162141; PMCID PMC5697417
DOI 10.1186/s12977-017-0377-y

Jakobsdottir, G.M., Iliopoulou, M., Nolan, R., Alvarez, L., Compton, A.A., and Padilla-Parra, S. (2017) On the whereabouts of HIV-1 cellular entry and its fusion ports. Trends Mol. Med. 23: 932-944.
Abstract     Full-text PDF     PMID 28899754     DOI 10.1016/j.molmed.2017.08.005

Monel, B., Compton, A.A., Bruel, T., Amraoui, S., Burlaud-Gaillard, J., Roy, N., Guivel-Benhassine, F., Porrot, F., Génin, P., Meertens, L., Sinigaglia, L., Jouvenet, N., Weil, R., Casartelli, N., Demangel, C., Simon-Lorière, E., Moris, A., Roingeard, P., Amara, A., and Schwartz, O. (2017) Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells. EMBO J. 36: 1653-1668.
Abstract     Full-text PDF     PMID 28473450; PMCID PMC5470047
DOI 10.15252/embj.201695597

Compton, A.A., and Schwartz, O. (2017) They might be giants: Does syncytium formation sink or spread HIV infection? PLoS Pathog. 13(2): e1006099.
Full-text PDF     PMID 28152024; PMCID PMC5289631     DOI 10.1371/journal.ppat.1006099

Cover

Compton, A.A., Roy, N., Porrot, F., Billet, A., Casartelli, N., Yount, J., Liang, C., and Schwartz, O. (2016) Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity. EMBO Rep. 17: 1657-1671.
Abstract     Full-text PDF     PMID 27601221; PMCID PMC5090704
DOI 10.15252/embr.201642771

Cover     About the cover

Compton, A.A., Bruel, T., Porrot, F., Mallet, A., Sachse, M., Euvrard, M., Liang, C., Casartelli, N., and Schwartz, O. (2014) IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe 16: 736-747.
Abstract     Full-text PDF     Supplemental information     PMID 25464829
DOI 10.1016/j.chom.2014.11.001

Related article: Fassati, A. (2014) Commentary: Fuse me IFITM can! Retrovirology 11: 104.

Compton, A.A., and Emerman, M. (2013) Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses. PLoS Pathog. 9(1): e1003135.
Abstract     Full-text PDF     Supporting information     PMID 23359341; PMCID PMC3554591
DOI 10.1371/journal.ppat.1003135

Featured in PLoS Collections: Immunobiology
Featured paper on This Week in Virology (TWiV) episode 237: Paleovirology

Compton, A.A., Malik, H.S., and Emerman, M. (2013) Host gene evolution traces the evolutionary history of ancient primate lentiviruses. Philos. Trans. R. Soc. Lond. B Biol. Sci. 368(1626): 20120496.
Abstract     Full-text PDF     PMID 23938749; PMCID PMC3758184
DOI 10.1098/rstb.2012.0496

Compton, A.A., Hirsch, V.M., and Emerman, M. (2012) The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict. Cell Host Microbe 11: 91-98. Abstract     Full-text PDF     Supplemental information
PMID 22264516; PMCID PMC3266539     DOI 10.1016/j.chom.2011.11.010


Last modified: 16 November 2018


NIH...Turning Discovery Into Health®

U.S. Department of Health and Human Services | National Institutes of Health | National Cancer Institute | USA.gov

Home | Contact | Policies | Accessibility | Viewing Files | FOIA