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Publications


PubMed summary

Google Scholar profile

Complete bibliography (updated February 2017)

Lippincott-Schwartz, J., Freed, E.O., and van Engelenburg, S.B.  (2017)  A consensus view of ESCRT-mediated human immunodeficiency virus type 1 abscission.  Annu. Rev. Virol., in press (Jul 17 Epub ahead of print).
Abstract     Full-text PDF from publisher     PMID 28715971

Martins, A.N., Ke, W., Jawahar, V., Striplin, M., Striplin, C., Freed, E.O., and Afonin, K.A.  (2017)  Intracellular reassociation of RNA-DNA hybrids that activates RNAi in HIV-infected cells.  In RNA Nanostructures: Methods and Protocols (E. Bindewald and B.A. Shapiro, eds.).  Methods in Molecular Biology, Vol. 1632, Humana Press, New York, NY, pp. 269-283.
Abstract     Full-text HTML version from publisher     PMID 28730446

Fernandez, M.V., and Freed, E.O.  (2017)  ‘Expand and click’: A new method for labeling HIV-1 envelope glycoproteins.  Cell Chem. Biol. 24: 548-550.
Abstract     Full-text PDF from publisher     PMID 28525770

Urano, E., Miyauchi, K., Kojima, Y., Hamatake, M., Ablan, S.D., Fudo, S., Freed, E.O., Hoshino, T., and Komano, J.  (2016)  A triazinone derivative inhibits HIV-1 replication by interfering with reverse transcriptase activity.  ChemMedChem 11: 2320-2326.
Abstract     Full-text PDF from publisher     Supporting information
PMID 27634404

Freed, E.O.  (2016)  Getting IN on viral RNA condensation and virion maturation.  Cell 166: 1082-1083.
Abstract     Full-text PDF from publisher     PMID 27565339

Timilsina, U., Ghimire, D., Timalsina, B., Nitz, T.J., Wild, C.T., Freed, E.O., and Gaur, R.  (2016)  Identification of potent maturation inhibitors against HIV-1 clade C.  Sci. Rep. 6: 27403.
Abstract     Full-text PDF from NIH Public Access
PMID 27264714; PMCID PMC4893694

Alfadhli, A., Mack, A., Ritchie, C., Cylinder, I., Harper, L., Tedbury, P.R., Freed, E.O., and Barklis, E.  (2016)  Trimer enhancement mutation effects on HIV-1 matrix protein binding activities.  J. Virol. 90: 5657-5664.
Abstract     Full-text PDF from NIH Public Access
PMID 27030269; PMCID PMC4886772

Waheed, A.A., MacDonald, S., Khan, M., Mounts, M., Swiderski, M., Xu, Y., Ye, Y., Freed, E.O.  (2016)  The Vpu-interacting protein SGTA regulates expression of a non-glycosylated tetherin species.  Sci. Rep. 6: 24934.
Abstract      Full-text PDF from NIH Public Access     Supplementary information
PMID 27103333; PMCID PMC4840321

Mercredi, P.Y., Bucca, N., Loeliger, B., Gaines, C.R., Mehta, M., Bhargava, P., Tedbury, P.R., Charlier, L., Floquet, N., Muriaux, D., Favard, C., Sanders, C.R., Freed, E.O.*, Marchant, J.*, and Summers, M.F.*  (2016)  Structural and molecular determinants of membrane binding by the HIV-1 matrix protein.  J. Mol. Biol. 428: 1637-1655.   *joint corresponding authors
Abstract      Full-text PDF from NIH Public Access     Supplementary data
PMID 26992353; PMCID PMC4836608

Afonin, K.A., Viard, M., Tedbury, P., Bindewald, E., Parlea, L., Howington, M., Valdman, M., Johns-Boehme, A., Brainerd, C., Freed, E.O., and Shapiro, B.A.  (2016)  The use of minimal RNA toeholds to trigger the activation of multiple functionalities.  Nano Lett. 16: 1746-1753.
Abstract     Full-text PDF from publisher     Supporting information
PMID 26926382

Tedbury, P.R., Novikova, M., Ablan, S.D., and Freed, E.O.  (2016)  Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation.  Proc. Natl. Acad. Sci. USA 113: E182-E190.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 26711999; PMCID PMC4720328

Fontana, J., Keller, P.W., Urano, E., Ablan, S.D., Steven, A.C., and Freed, E.O.  (2016)  Identification of an HIV-1 mutation in spacer peptide 1 that stabilizes the immature CA-SP1 lattice.  J. Virol. 90: 972-978.
Abstract     Full-text PDF from NIH Public Access
PMID 26537676; PMCID PMC4702660

Martins, A.N., Waheed, A.A., Ablan, S.D., Huang, W., Newton, A., Petropoulos, C.J., Brindeiro, R.M., and Freed, E.O.  (2016)  Elucidation of the molecular mechanism driving duplication of the HIV-1 PTAP late domain.  J. Virol. 90: 768-779.
Abstract     Full-text PDF from NIH Public Access
PMID 26512081; PMCID PMC4702686

Urano, E., Ablan, S.D., Mandt, R., Pauly, G.T., Sigano, D.M., Schneider, J.P., Martin, D.E., Nitz, T.J., Wild, C.T., and Freed, E.O.  (2016)  Alkyl amine bevirimat derivatives are potent and broadly active HIV-1 maturation inhibitors.  Antimicrob. Agents Chemother. 60: 190-197.
Abstract      Full-text PDF from NIH Public Access     Supplemental material
PMID 26482309; PMCID PMC4704169

Yu, J., Li, M., Wilkins, J., Ding, S., Swartz, T.H., Esposito, A.M., Zheng, Y.-M., Freed, E.O., Liang, C., Chen, B.K., and Liu, S.-L.  (2015)  IFITM proteins restrict HIV-1 infection by antagonizing the envelope glycoprotein.  Cell Rep. 13: 145-156.
Abstract      Full-text PDF from NIH Public Access     Supplemental information
PMID 26387945; PMCID PMC4602366

Freed, E.O.  (2015)  HIV assembly, release and maturation.  Nature Rev. Microbiol. 13: 484-496.
Abstract      Full-text PDF from publisher     PMID 26119571

Gerber, P.P., Cabrini, M., Jancic, C., Paoletti, L., Banchio, C., von Bilderling, C., Sigaut, L., Pietrasanta, L.I., Duette, G., Freed, E.O., de Saint Basile, G., Moita, C.F., Moita, L.F., Amigorena, S., Benaroch, P., Geffner, J., and Ostrowski, M.  (2015)  Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate.  J. Cell Biol. 209: 435-452.
Abstract      Full-text PDF from NIH Public Access     Supplemental data
PMID 25940347; PMCID PMC4427790

Brown, L.A., Cox, C., Baptiste, J., Summers, H., Button, R., Bahlow, K., Spurrier, V., Kyser, J., Luttge, B.G., Kuo, L., Freed, E.O.*, and Summers, M.F.*  (2015)  NMR structure of the myristylated feline immunodeficiency virus matrix protein.  Viruses 7: 2210-2229.
*joint corresponding author
Abstract      Full-text PDF from NIH Public Access     Supplementary material
PMID 25941825; PMCID PMC4452903

Tedbury, P.R., and Freed, E.O.  (2015)  HIV-1 Gag: An emerging target for antiretroviral therapy.  Curr. Top. Microbiol. Immunol. 389: 171-201.
Abstract     Full-text PDF from publisher     PMID 25731773

Tedbury, P.R., Mercredi, P.Y., Gaines, C.R., Summers, M.F., and Freed, E.O.  (2015)  Elucidating the mechanism by which compensatory mutations rescue an HIV-1 matrix mutant defective for Gag membrane targeting and envelope glycoprotein incorporation.  J. Mol. Biol. 427: 1413-1427.
Abstract      Full-text PDF from NIH Public Access
PMID 25659909; PMCID PMC4844178

Tedbury, P., and Freed, E.O.  (2015)  The cytoplasmic tail of retroviral envelope glycoproteins.  In The Molecular Basis of Viral Infection (P.J. Klasse, ed.), Progress in Molecular Biology and Translational Science, Volume 129, Elsevier, Inc., pp. 253-284.
Abstract     Full-text PDF from publisher      PMID 25595807

Tedbury, P.R., and Freed, E.O.  (2014)  Virus assembly.  In Encyclopedia of AIDS (T.J. Hope, M. Stevenson, and D. Richman, eds.), Springer, pp. 1-11,
DOI 10.1007/978-1-4614-9610-6_55-1.     Excerpt from publisher

Kuo, L.S., and Freed, E.O.  (2014)  HIV-1 assembly cofactors.  In Encyclopedia of AIDS (T.J. Hope, M. Stevenson, and D. Richman, eds.), Springer, pp. 1-9,
DOI 10.1007/978-1-4614-9610-6_75-1.     Excerpt from publisher

Park, S.-Y., Waheed, A.A., Zhang, Z.R., Freed, E.O., and Bonifacino, J.S.  (2014)  HIV-1 Vpu induces caspase-mediated cleavage of IRF3 transcription factor.  J. Biol. Chem. 289: 35102-35110.
Abstract      Full-text PDF from NIH Public Access
PMID 25352594; PMCID PMC4271200

Afonin, K.A., Viard, M., Koyfman, A.Y., Martins, A.N., Kasprzak, W.K., Panigaj, M., Desai, R., Santhanam, A., Grabow, W.W., Jaeger, L., Heldman, E., Reiser, J., Chiu, W., Freed, E.O., and Shapiro, B.A.  (2014)  Multifunctional RNA nanoparticles.  Nano Lett. 14: 5662-5671.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 25267559; PMCID PMC4189619

Waheed, A.A., Kuruppu, N.D., Felton, K.L., D'Souza, D., and Freed, E.O.  (2014)  In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.  PLoS One 9(10): e111628.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 25360760; PMCID PMC4216104

Bird, S.W., Kirkegaard, K., Agbandje-McKenna, M., and Freed, E.O.  (2014)  The ins and outs of viral infection: Keystone meeting review.  Viruses 6: 3652-3662.
Abstract      Full-text PDF from NIH Public Access
PMID 25256395; PMCID PMC4189043

Li, M., Ablan, S.D., Miao, C., Zheng, Y.-M., Fuller, M.S., Rennert, P.D., Maury, W., Johnson, M.C., Freed, E.O., and Liu, S.-L.  (2014)  TIM-family proteins inhibit HIV-1 release.  Proc. Natl. Acad. Sci. USA 111: E3699-E3707.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 25136083; PMCID PMC4156686

Chen, A.K., Sengupta, P., Waki, K., Van Engelenburg, S.B., Ochiya, T., Ablan, S.D., Freed, E.O., and Lippincott-Schwartz, J.  (2014)  MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.  Proc. Natl. Acad. Sci. USA 111: E2676-E2683.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 24938790; PMCID PMC4084429

Tedbury, P.R., and Freed, E.O.  (2014)  The role of matrix in HIV-1 envelope glycoprotein incorporation.  Trends Microbiol. 22: 372-378.
Abstract      Full-text PDF from NIH Public Access
PMID 24933691; PMCID PMC4157688

Luttge, B.G., Panchal, P., Puri, V., Checkley, M.A., and Freed, E.O.  (2014)  Mutations in the feline immunodeficiency virus envelope glycoprotein confer resistance to a dominant-negative fragment of Tsg101 by enhancing infectivity and cell-to-cell virus transmission.  Biochim. Biophys. Acta 1838: 1143-1152.
Abstract      Full-text PDF from NIH Public Access
PMID 24036228; PMCID PMC3943682

Freed, E.O., and Gale, M., Jr.  (2014)  Antiviral innate immunity: Editorial overview.  J. Mol. Biol. 426: 1129-1132.
PubMed citation      Full-text PDF from publisher     PMID 24462565

Van Engelenburg, S.B., Shtengel, G., Sengupta, P., Waki, K., Jarnik, M., Ablan, S.D., Freed, E.O., Hess, H.F., and Lippincott-Schwartz, J.  (2014)  Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits.  Science 343: 653-656.
Abstract      Full-text PDF from NIH Public Access     Supplementary material
PMID 24436186; PMCID PMC4791044

Daniels, S.I., Soule, E.E., Davidoff, K.S., Bernbaum, J.G., Hu, D., Maeda, K., Stahl, S.J., Naiman, N.E., Waheed, A.A., Freed, E.O., Wingfield, P., Yarchoan, R., and Davis, D.A.  (2014)  Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide.  FASEB J. 28: 106-116.
Abstract      Full-text PDF from publisher     Supplemental data
PMID 24097312; PMCID PMC3868840

Zhang, H., Curreli, F., Waheed, A.A., Mercredi, P.Y., Mehta, M., Bhargava, P., Scacalossi, D., Tong, X., Lee, S., Cooper, A., Summers, M.F., Freed, E.O., and Debnath, A.K.  (2013)  Dual-acting stapled peptides target both HIV-1 entry and assembly.  Retrovirology 10: 136.
Abstract      Full-text PDF from NIH Public Access     Supplemental material
PMID 24237936; PMCID PMC3842668

Keller, P.W., Huang, R.K., England, M.R., Waki, K., Cheng, N., Heymann, J.B., Craven, R.C., Freed, E.O., and Steven, A.C.  (2013)  A two-pronged structural analysis of retroviral maturation suggests that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.  J. Virol. 87: 13655-13664.
Abstract      Full-text PDF from NIH Public Access
PMID 24109217; PMCID PMC3838239

Tedbury, P.R., Ablan, S.D., and Freed, E.O.  (2013)  Global rescue of defects in HIV-1 envelope glycoprotein incorporation: Implications for matrix structure.  PLoS Pathog. 9(11): e1003739.
Abstract      Full-text PDF from NIH Public Access
PMID 24244165; PMCID PMC3828165

Freed, E.O., and Martin, M.A.  (2013)  Human immunodeficiency virus: Replication.  In Fields Virology, 6th Edition (D.M. Knipe and P.M. Howley, eds.), Volume 2, Lippincott, Williams, and Wilkins, Philadelphia, pp. 1502-1560.

Freed, E.O., ed.  (2013)  Advances in HIV-1 Assembly and Release, Springer International Publishing, Switzerland.

Afonin, K.A., Viard, M., Martins, A.N., Lockett, S.J., Maciag, A.E., Freed, E.O., Heldman, E., Jaeger, L., Blumenthal, R., and Shapiro, B.A.  (2013)  Activation of different split functionalities on re-association of RNA-DNA hybrids.  Nat. Nanotechnol. 8: 296-304.
Abstract      Full-text PDF from NIH Public Access
Supplementary information     PMID 23542902; PMCID PMC3618561

Related Article:  Novel approach using DNA-RNA hybrids in RNA nanotechnology.  National Cancer Institute, Center for Cancer Research, News | headlines, April 2013.

Keren-Kaplan, T., Attali, I., Estrin, M., Kuo, L.S., Farkash, E., Jerabek-Willemsen, M., Blutraich, N., Artzi, S., Peri, A., Freed, E.O., Wolfson, H.J., and Prag, G.  (2013)  Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding.  EMBO J. 32: 538-551.
Abstract      Full-text PDF from NIH Public Access     Supplementary information
PMID 23361315; PMCID PMC3579145

Checkley, M.A., Luttge, B.G., Mercredi, P.Y., Kyere, S.K., Donlan, J., Murakami, T., Summers, M.F., Cocklin, S., and Freed, E.O.  (2013)  Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation.  J. Virol. 87: 3561-3570.
Abstract     Full-text PDF from NIH Public Access
PMID 23325685; PMCID PMC3592152

Waki, K., Durell, S.R., Soheilian, F., Nagashima, K., Butler, S.L., and Freed, E.O.  (2012)  Structural and functional insights into the HIV-1 maturation inhibitor binding pocket.  PLoS Pathog. 8(11): e1002997.
Abstract     Full-text PDF from NIH Public Access     Supporting information
PMID 23144615; PMCID PMC3493477

Matreyek, K.A., Oztop, I., Freed, E.O., and Engelman, A.  (2012)  Viral latency and potential eradication of HIV-1.  Expert Rev. Anti-Infect. Ther. 10: 855-857.
Abstract     Full-text PDF from NIH Public Access
PMID 23030323; PMCID PMC3573755

Kuo, L., and Freed, E.O.  (2012)  ARRDC1 as a mediator of microvesicle budding.  Proc. Natl. Acad. Sci. USA 109: 4025-4026.
PubMed citation     Full-text PDF from NIH Public Access
PMID 22378650; PMCID PMC3306698

Waheed, A.A., and Freed, E.O.  (2012)  HIV type 1 Gag as a target for antiviral therapy.  AIDS Res. Hum. Retroviruses 28: 54-75.
Abstract     Full-text PDF from NIH Public Access
PMID 21848364; PMCID PMC3251841

Jiang, J., Ablan, S., Derebail, S., Hercik, K., Soheilian, F., Thomas, J.A., Tang, S., Hewlett, I., Nagashima, K., Gorelick, R.J., Freed, E.O., and Levin, J.G.  (2011)  The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.  Virology 421: 253-265.
Abstract     Full-text PDF from NIH Public Access
PMID 22036671; PMCID PMC3573886

Joshi, A., Garg, H., Ablan, S.D., and Freed, E.O.  (2011)  Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release.  J. Biol. Chem. 286: 29861-29871.
Abstract     Full-text PDF from NIH Public Access
PMID 21680744; PMCID PMC3191027

Checkley, M.A., Luttge, B.G., and Freed, E.O.  (2011)  HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.  J. Mol. Biol. 410: 582-608.
Abstract     Full-text PDF from NIH Public Access
PMID 21762802; PMCID PMC3139147

Balasubramaniam, M., and Freed, E.O.  (2011)  New insights into HIV assembly and trafficking.  Physiology 26: 236-251.
Abstract     Full-text PDF from NIH Public Access
PMID 21841072; PMCID PMC3467973

Joshi, A., Garg, H., Ablan, S., Freed, E.O., Nagashima, K., Manjunath, N., and Shankar, P.  (2011)  Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy.  Virology 415: 95-106.
Abstract      Full-text PDF from NIH Public Access     Supplementary data
PMID 21529874; PMCID PMC3107932

Lu, W., Salzwedel, K., Wang, D., Chakravarty, S., Freed, E.O., Wild, C.T., and Li, F.  (2011)  A single polymorphism in HIV-1 subtype C SP-1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.  Antimicrob. Agents Chemother. 55: 3324-3329.
Abstract     Full-text PDF from NIH Public Access
PMID 21502630; PMCID PMC3122462

Kim, S.-E., Liu, F., Im, Y.J., Stephen, A.G., Fivash, M.J., Waheed, A.A., Freed, E.O., Fisher, R.J., Hurley, J.H., and Burke, T.R.  (2011)  Elucidation of new binding interactions with the human Tsg101 protein using modified HIV-1 Gag-p6 derived peptide ligands.  ACS Med. Chem. Lett. 2: 337-341.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 21643473; PMCID PMC3105896

Zhang, H., Curreli, F., Zhang, X., Bhattacharya, S., Waheed, A.A., Cooper, A., Cowburn, D., Freed, E.O., and Debnath, A.K.  (2011)  Antiviral activity of alpha-helical stapled peptides designed from the HIV-1 capsid dimerization domain.  Retrovirology 8: 28.
Abstract     Full-text PDF from NIH Public Access
PMID 21539734; PMCID PMC3097154

Keller, P.W., Adamson, C.S., Heymann, J.B., Freed, E.O., and Steven, A.C.  (2011)  HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.  J. Virol. 85: 1420-1428.
Abstract      Full-text PDF from NIH Public Access     Supplemental material
PMID 21106735; PMCID PMC3028903

Freed, E.O., and Simon, A.  (2010)  Review of EMBO World Lecture Course "Virus-host: partners in pathogenesis."  Future Virol. 5: 379-383.
Abstract     Full-text PDF from publisher

Waki, K., and Freed, E.O.  (2010)  Macrophages and cell-cell spread of HIV-1. Viruses 2: 1603-1620.
Abstract     Full-text PDF from NIH Public Access
PMID 21552427; PMCID PMC3088113

Im, Y.J., Kuo, L., Ren, X., Burgos, P.V., Zhao, X.-Z., Liu, F., Burke, T.R., Jr., Bonifacino, J.S., Freed, E.O., and Hurley, J.H.  (2010)  Crystallographic and functional analysis of the ESCRT-1/HIV-1 Gag PTAP interaction.  Structure 18: 1536-1547.
Abstract     Full-text PDF from NIH Public Access
PMID 21070952; PMCID PMC3124085

Fledderman, E.L., Fujii, K., Ghanam, R.H., Waki, K., Prevelige, P.E., Freed, E.O., and Saad, J.S.  (2010)  Myristate exposure in the HIV-1 matrix protein is modulated by pH.  Biochemistry 49: 9551-9562.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 20886905; PMCID PMC3032006

Waheed, A.A., and Freed, E.O.  (2010)  The role of lipids in retrovirus replication. Viruses 2: 1146-1180.
Abstract     Full-text PDF from NIH Public Access
PMID 20740061; PMCID PMC2927015

Adamson, C.S., Sakalian, M., Salzwedel, K., and Freed, E.O.  (2010)  Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat.  Retrovirology 7: 36.
Abstract     Full-text PDF from NIH Public Access
PMID 20406463; PMCID PMC2873507

Checkley, M.A., Luttge, B.G., Soheilian, F., Nagashima, K., and Freed, E.O.  (2010)  The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.  Virology 400: 137-144.
Abstract     Full-text PDF from NIH Public Access
PMID 20172577; PMCID PMC2838455

Waheed, A.A., Ablan, S.D., Sowder, R.C., Roser, J.D., Schaffner, C.P., Chertova, E., and Freed, E.O.  (2010)  Effect of mutations in the human immunodeficiency virus type 1 protease on cleavage of the gp41 cytoplasmic tail.  J. Virol. 84: 3121-3126.
Abstract     Full-text PDF from NIH Public Access
PMID 20042499; PMCID PMC2826043

Luttge, B.G., and Freed, E.O.  (2010)  FIV Gag: Virus assembly and host-cell interactions.  Vet. Immunol. Immunopath. 134: 3-13.
Abstract     Full-text PDF from NIH Public Access
PMID 19910057; PMCID PMC2822131

Liu, F., Stephen, A.G., Waheed, A.A., Freed, E.O., Fisher, R.J., and Burke, T.R., Jr.  (2010)  Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists.  Bioorg. Med. Chem. Lett. 20: 318-321.
Abstract      Full-text PDF from NIH Public Access     Supplementary data
PMID 19914066; PMCID PMC2818493

Adamson, C.S., and Freed, E.O.  (2010)  Novel approaches to inhibiting HIV-1 replication.  Antiviral Res. 85: 119-141.
Abstract     Full-text PDF from NIH Public Access
PMID 19782103; PMCID PMC2815006

Joshi, A., Nagashima, K., and Freed, E.O.  (2009)  Defects in cellular sorting and retroviral assembly induced by GGA overexpression.  BMC Cell Biol. 10: 72.
Abstract     Full-text PDF from NIH Public Access
PMID 19788741; PMCID PMC2760529

Bennett, A.E., Narayan, K., Shi, D., Hartnell, L.M., Gousset, K., He, H., Lowekamp, B.C., Yoo, T.S., Bliss, D., Freed, E.O., and Subramaniam, S.  (2009)  Ion-abrasion scanning electron microscopy reveals surface-connected tubular conduits in HIV-infected macrophages.  PLoS Pathog. 5: e1000591.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 19779568; PMCID PMC2743285

Fujii, K., Munshi, U.M., Ablan, S.D., Demirov, D.G., Soheilian, F., Nagashima, K., Stephen, A.G., Fisher, R.J., and Freed, E.O.  (2009)  Functional role of Alix in HIV-1 replication. Virology 391: 284-292.
Abstract     Full-text PDF from NIH Public Access
PMID 19596386; PMCID PMC2744943

Waheed, A.A., and Freed, E.O.  (2009)  Lipids and membrane microdomains in HIV-1 replication.  Virus Res. 143: 162-176.
Abstract     Full-text PDF from NIH Public Access
PMID 19383519; PMCID PMC2731011

Adamson, C.S., Salzwedel, K., and Freed, E.O.  (2009)  Virus maturation as a new HIV-1 therapeutic target.  Expert Opin. Ther. Targets 13: 895-908.
Abstract     Full-text PDF from NIH Public Access
PMID 19534569; PMCID PMC2737327

Joshi, A., Ablan, S.D., Soheilian, F., Nagashima, K., and Freed, E.O.  (2009)  Evidence that productive human immunodeficiency virus type 1 assembly can occur in an intracellular compartment.  J. Virol. 83: 5375-5387.
Abstract      Full-text PDF from NIH Public Access     Supplemental material
PMID 19297499; PMCID PMC2681934

Adamson, C.S., and Freed, E.O.  (2009)  Anti-HIV-1 therapeutics: From FDA-approved drugs to hypothetical future targets.  Mol. Intervent. 9: 70-74.
PubMed citation     Full-text PDF from NIH Public Access
PMID 19401538; PMCID PMC2861802

Adamson, C.S., Waki, K., Ablan, S.D., Salzwedel, K., and Freed, E.O.  (2009)  Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457).  J. Virol. 83: 4884-4894.
Abstract      Full-text PDF from NIH Public Access     Supplemental material
PMID 19279107; PMCID PMC2682084

Waheed, A.A., Ono, A., and Freed, E.O.  (2009)  Methods for the study of HIV-1 assembly.  In HIV Protocols, 2nd Edition (V.R. Prasad and G.V. Kalpana, eds.), Methods in Molecular Biology, Volume 485, Humana Press, pp. 163-184.
Abstract     Full-text PDF from publisher     PMID 19020825

Waheed, A.A., and Freed, E.O.  (2008)  Peptide inhibitors of HIV-1 egress.  ACS Chem. Biol. 3: 745-747.
Abstract     Full-text PDF from publisher     PMID 19099395

Greene, W.C., Debyser, Z., Ikeda, Y., Freed, E.O., Stephens, E., Yonemoto, W., Buckheit, R.W., Este, J.A., and Cihlar, T.  (2008)  Novel targets for HIV therapy.  Antiviral Res. 80: 251-265.
Abstract     Full-text PDF from publisher     PMID 18789977

Joshi, A., Munshi, U., Ablan, S.D., Nagashima, K., and Freed, E.O.  (2008)  Functional replacement of a retroviral late domain by ubiquitin fusion.  Traffic 9: 1972-1983.
Abstract     Full-text PDF from NIH Public Access
PMID 18817521; PMCID PMC2763539

Waheed, A.A., Ablan, S.D., Soheilian, F., Nagashima, K., Ono, A., Schaffner, C.P., and Freed, E.O.  (2008)  Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: Evidence for Vpu dependence.  J. Virol. 82: 9776-9781.
Abstract     Full-text PDF from NIH Public Access
PMID 18653459; PMCID PMC2546975

Saad, J.S., Ablan, S.D., Ghanam, R.H., Kim, A., Andrews, K., Nagashima, K., Soheilian, F., Freed, E.O., and Summers, M.F.  (2008)  Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.  J. Mol. Biol. 382: 434-447.
Abstract     Full-text PDF from NIH Public Access
PMID 18657545; PMCID PMC2581411

Liu, F., Stephen, A.G., Waheed, A.A., Aman, M.J., Freed, E.O., Fisher, R.J., and Burke, T.R., Jr.  (2008)  SAR by oxime-containing peptide libraries: Application to Tsg101 ligand optimization.  ChemBioChem 9: 2000-2004.
Abstract     Full-text PDF from NIH Public Access
PMID 18655064; PMCID PMC2581409

Adamson, C.S., and Freed, E.O.  (2008)  Recent progress in antiretrovirals – lessons from resistance.  Drug Discov. Today 13: 424-432.
Abstract     Full-text PDF from NIH Public Access
PMID 18468560; PMCID PMC2581412

Joshi, A., Garg, H., Nagashima, K., Bonifacino, J.S., and Freed, E.O.  (2008)  GGA and Arf proteins modulate retrovirus assembly and release.  Mol. Cell 30: 227-238.
Abstract      Full-text PDF from NIH Public Access     Supplemental data
PMID 18439901; PMCID PMC2386562

Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, A.A., Tong, X., Hong, A., Heck, S., Curreli, F., Goger, M., Cowburn, D., Freed, E.O., and Debnath, A.K.  (2008)  A cell-penetrating helical peptide as a potential HIV-1 inhibitor.  J. Mol. Biol. 378: 565-580.
Abstract      Full-text PDF from NIH Public Access     Supplementary data
PMID 18374356; PMCID PMC2695608

Gousset, K., Ablan, S.D., Coren, L.V., Ono, A., Soheilian, F., Nagashima, K., Ott, D.E., and Freed, E.O.  (2008)  Real-time visualization of HIV-1 Gag trafficking in infected macrophages.  PLoS Pathog. 4: e1000015.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 18369466; PMCID PMC2695608

Viard, M., Ablan, S.D., Zhou, M., Veenstra, T.D., Freed, E.O., Raviv, Y., and Blumenthal, R.  (2008)  Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 gp41 cytoplasmic tail into the viral membrane.  Biochemistry 47: 1977-1983.
Abstract     Full-text PDF from NIH Public Access
PMID 18198900; PMCID PMC2583176

Luttge, B.G., Shehu-Xhilaga, M., Demirov, D.G., Adamson, C.S., Soheilian, F., Nagashima, K., Stephen, A.G., Fisher, R.J., and Freed, E.O..  (2008)  Molecular characterization of feline immunodeficiency virus budding.  J. Virol. 82: 2106-2109.
Abstract     Full-text PDF from NIH Public Access
PMID 18094166; PMCID PMC2258934

Fujii, K., Hurley, J.H., and Freed, E.O.  (2007)  Beyond Tsg101: The role of Alix in 'ESCRTing' HIV-1.  Nat. Rev. Microbiol. 5: 912-916.
Abstract     Full-text PDF from publisher     PMID 17982468

Joshi, A., and Freed, E.O.  (2007)  HIV-1 Gag trafficking.  Future HIV Ther. 1: 427-438.
Abstract     Full-text PDF from publisher

Waheed, A.A., and Freed, E.O.  (2007)  Influenza virus not cRAFTy enough to dodge viperin.  Cell Host Microbe 2: 71-72.
Abstract     Full-text PDF from publisher     PMID 18005719

Adamson, C.S., and Freed, E.O.  (2007)  Human immunodeficiency virus type 1 assembly, release, and maturation.  In HIV-1: Molecular Biogenesis and Pathogenesis: Viral Mechanisms, 2nd Edition (K.-T. Jeang, ed.), Advances in Pharmacology, Volume 55, Elsevier Inc., pp. 347-387.
PubMed citation     Full-text PDF from publisher     PMID 17586320

Garg, H., Joshi, A., Freed, E.O., and Blumenthal, R.  (2007)  Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion/hemifusion. J. Biol. Chem. 282: 16899-16906.
Abstract      Full-text PDF from publisher     Supplemental data
PMID 17416587

Waheed, A.A., Ablan, S.D., Roser, J.D., Sowder, R.C., Schaffner, C.P., Chertova, E., and Freed, E.O.  (2007)  HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease.  Proc. Natl. Acad. Sci. USA 104: 8467-8471.
Abstract      Full-text PDF from NIH Public Access
PMID 17483482; PMCID PMC1895973

Related Article:  HIV and drug resistance: Hitting a moving target. National Cancer Institute, Center for Cancer Research, News | headlines, December 2007.

Lee, S., Joshi, A., Nagashima, K., Freed, E.O., and Hurley, J.H.  (2007)  Structural basis for viral late-domain binding to Alix.  Nat. Struct. Mol. Biol. 14: 194-199.
Abstract     Full-text PDF from NIH Public Access
PMID 17277784; PMCID PMC2377018

Ono, A., Waheed, A.A., and Freed, E.O.  (2007)  Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag.  Virology 360: 27-35.
Abstract     Full-text PDF from NIH Public Access
PMID 17095032; PMCID PMC1945131

Freed, E.O., and Martin, M.A.  (2007)  HIVs and their replication.  Chapter 57. In Fields Virology, 5th Edition (D.M. Knipe and P.M. Howley, eds.), Lippincott, Williams, and Wilkins, Philadelphia, pp. 2107-2186.

Munshi, U.M., Kim, J., Nagashima, K., Hurley, J.H., and Freed, E.O.  (2007)  An Alix fragment potently inhibits HIV-1 budding: Characterization of binding to retroviral YPXL late domains.  J. Biol. Chem. 282: 3847-3855.
Abstract     Full-text PDF from publisher     PMID 17158451

Saad, J.S., Loeliger, E., Luncsford, P., Liriano, M., Tai, J., Kim, A., Miller, J., Joshi, A., Freed, E.O., and Summers, M.F.  (2007)  Point mutations in the HIV-1 matrix protein turn off the myristyl switch.  J. Mol. Biol. 366: 574-585.
Abstract      Full-text PDF from NIH Public Access     Supplementary data
PMID 17188710; PMCID PMC1853300

Tang, S., Ablan, S., Dueck, M., Ayala-López, W., Soto, B., Caplan, M., Nagashima, K., Hewlett, I.K., Freed, E.O., and Levin, J.G.  (2007)  A second-site suppressor significantly improves the defective phenotype imposed by mutation of an aromatic residue in the N-terminal domain of the HIV-1 capsid protein.  Virology 359: 105-115.
Abstract     Full-text PDF from NIH Public Access
PMID 17055023; PMCID PMC1851891

Freed, E.O., and Mouland, A.O.  (2006)  Meeting Review: The cell biology of HIV-1 and other retroviruses.  Retrovirology 3: 77-87.
Abstract     Full-text PDF from NIH Public Access
PMID 17083721; PMCID PMC1635732

Li, F., Zoumplis, D., Matallana, C., Kilgore, N.R., Reddick, M., Yunus, A.S., Adamson, C.S., Salzwedel, K., Martin, D.E., Allaway, G.P., Freed, E.O., and Wild, C.T.  (2006)  Determinants of activity of the HIV-1 maturation inhibitor PA-457.  Virology 356: 217-224.
Abstract     Full-text PDF from publisher     PMID 16930665

Adamson, C.S., Ablan, S.D., Boeras, I., Goila-Gaur, R., Soheilian, F., Nagashima, K., Li, F., Salzwedel, K., Sakalian, M., Wild, C.T., and Freed, E.O.  (2006)  In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (bevirimat).  J. Virol. 80: 10957-10971.
Abstract     Full-text PDF from NIH Public Access
PMID 16956950; PMCID PMC1642185

Liu, F., Stephen, A.G., Adamson, C.S., Gousset, K., Aman, M.J., Freed, E.O., Fisher, R.J., and Burke, T.R., Jr.  (2006)  Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: Application to the preparation of Tsg101-directed HIV-1 budding antagonists.  Org. Lett. 8: 5165-5168.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 17048869; PMCID PMC2547129

Waheed, A.A., Ablan, S.D., Mankowski, M.K., Cummins, J.E., Ptak, R.G., Schaffner, C.P., and Freed, E.O.  (2006)  Inhibition of HIV-1 replication by amphotericin B methyl ester: Selection for resistant variants.  J. Biol. Chem. 281: 28699-28711.
Abstract     Full-text PDF from publisher     PMID 16882663

Joshi, A., Nagashima, K., and Freed, E.O.  (2006)  Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, Gag-Gag interactions, Gag-membrane binding, and virion maturation.  J. Virol. 80: 7939-7951.
Abstract     Full-text PDF from NIH Public Access
PMID 16873251; PMCID PMC1563813

Freed, E.O.  (2006)  HIV-1 Gag: Flipped out for PI(4,5)P2.  Proc. Natl. Acad. Sci. USA 103: 11101-11102.
PubMed citation     Full-text PDF from NIH Public Access
PMID 16847255; PMCID PMC1544048

Davis, M.R., Jiang, J., Zhou, J., Freed, E.O., and Aiken, C.  (2006)  A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.  J. Virol. 80: 2405-2417.
Abstract     Full-text PDF from NIH Public Access
PMID 16474147; PMCID PMC1395406

Fu, W., Dang, Q., Nagashima, K., Freed, E.O., Pathak, V.K., and Hu, W.-S.  (2006)  Effects of Gag mutation and processing on retroviral dimeric RNA maturation.  J. Virol. 80: 1242-1249.
Abstract     Full-text PDF from NIH Public Access
PMID 16415001; PMCID PMC1346957

Ono, A., Waheed, A.A., Joshi, A., and Freed, E.O.  (2005)  Association of human immunodeficiency virus type 1 Gag with membrane does not require highly basic sequences in the nucleocapsid: Use of a novel Gag multimerization assay.  J. Virol. 79: 14131-14140.
Abstract     Full-text PDF from NIH Public Access
PMID 16254348; PMCID PMC1280195

Ono, A., and Freed, E.O.  (2005)  Role of lipid rafts in virus replication.  Adv. Virus Res. 64: 311-358.
PubMed citation     Full-text PDF from publisher     PMID 16139599

Sklar, P.A., Masur, H., Grubb, J.R., Voell, J., Witek, J., Ono, A., Freed, E.O., and Maldarelli, F.  (2005)  Pravastin does not have a consistent antiviral effect in chronically HIV-infected individuals on antiretroviral therapy.  AIDS 19: 1109-1111.
PubMed citation     Full-text PDF from publisher     PMID 15958846

Demirov, D.G., and Freed, E.O.  (2004)  Retrovirus budding.  In Mechanisms of Enveloped Virus Release (E.O. Freed, ed.), Virus Research, Volume 106, pp. 87-102.
Abstract     Full-text PDF from publisher     PMID 15567490

Freed, E.O.  (2004)  Preface.  In Mechanisms of Enveloped Virus Release (E.O. Freed, ed.), Virus Research, Vol. 106, pp. 85-86.
Abstract     Full-text PDF from publisher     PMID 15567489

Ono, A., Ablan, S.D., Lockett, S.J., Nagashima, K., and Freed, E.O.  (2004)  Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.  Proc. Natl. Acad. Sci. USA 101: 14889-14894.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 15465916; PMCID PMC522033

Freed, E.O., and Ross, S.R.  (2004)  Retroviruses 2004: Review of the 2004 Cold Spring Harbor Retroviruses conference.  Retrovirology 1: 25 (E-pub).
Abstract     Full-text PDF from NIH Public Access
PMID 15357866; PMCID PMC519032

Svarovskaia, E.S., Xu, H., Mbisa, J.L., Barr, R., Gorelick, R.J., Ono, A., Freed, E.O., Hu, W.-S., and Pathak, V.K.  (2004)  Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.  J. Biol. Chem. 279: 35822-35828.
Abstract     Full-text PDF from publisher     PMID 15210704

Freed, E.O.  (2004)  HIV-1 and the host cell: An intimate association.  Trends Microbiol. 12: 170-177.
PubMed citation     Full-text PDF from publisher     PMID 15051067

Ono, A., and Freed, E.O.  (2004)  Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body.  J. Virol. 78: 1552-1563.
Abstract     Full-text PDF from NIH Public Access
PMID 14722309; PMCID PMC321403

Murakami, T., Ablan, S., Freed, E.O., and Tanaka, Y.  (2004)  Regulation of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease activity.  J. Virol. 78: 1026-1031.
Abstract     Full-text PDF from NIH Public Access
PMID 14694135; PMCID PMC368813

Shehu-Xhilaga, M., Ablan, S., Demirov, D.G., Chen, C., Montelaro, R.C., and Freed, E.O.  (2004)  Late domain-dependent inhibition of equine infectious anemia virus budding.  J. Virol. 78: 724-732.
Abstract     Full-text PDF from NIH Public Access
PMID 14694104; PMCID PMC368837

Tang, S., Murakami, T., Cheng, N., Stephen, A.C., Freed, E.O., and Levin, J.G.  (2003)  Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase.  J. Virol. 77: 12592-12602.
Abstract     Full-text PDF from NIH Public Access
PMID 14610182; PMCID PMC262599

Li, F., Goila-Gaur, R., Salzwedel, K., Kilgore, N.R., Reddick, M., Matallana, C., Castillo, A., Zoumplis, D., Martin, D.E., Orenstein, J.M., Allaway, G.P., Freed, E.O., and Wild, C.T.  (2003)  PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.  Proc. Natl. Acad. Sci. USA 100: 13555-13560.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 14573704; PMCID PMC263852

Goila-Gaur, R., Demirov, D.G., Orenstein, J.M, Ono, A., and Freed, E.O.  (2003)  Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression.  J. Virol. 77: 6507-6519.
Abstract     Full-text PDF from NIH Public Access
PMID 12743307; PMCID PMC155030

Freed, E.O.  (2003)  The HIV-TSG101 interface: Recent advances in a budding field.  Trends Microbiol. 11: 56-59.
Abstract     Full-text PDF from publisher     PMID 12598123

Farr, S.A., Banks, W.A., Uezu, K., Freed, E.O., Kumar, V.B., and Morley, J.E.  (2002)  Mechanisms of HIV type 1-induced cognitive impairment: evidence for hippocampal cholinergic involvement with overstimulation of the VIPergic system by the viral coat protein core.  AIDS Res. Hum. Retroviruses 18: 1189-1195.
Abstract     Full-text PDF from publisher     PMID 12487825

Freed, E.O.  (2002)  Viral late domains.  J. Virol. 76: 4679-4687.
PubMed citation     Full-text PDF from NIH Public Access
PMID 11967285; PMCID PMC136167

Freed, E.O.  (2002)  Rafting with Ebola.  Science 296: 279.
PubMed citation     Full-text PDF from publisher     PMID 11951027

Demirov, D.G., Orenstein, J.M., and Freed, E.O.  (2002)  The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner.  J. Virol. 76: 105-117.
Abstract     Full-text PDF from NIH Public Access
PMID 11739676; PMCID PMC135729

Demirov, D.G., Ono, A., Orenstein, J.M., and Freed, E.O.  (2002)  Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.  Proc. Natl. Acad. Sci. USA 99: 955-960.
Abstract     Full-text PDF from NIH Public Access
PMID 11805336; PMCID PMC117412

Freed, E.O., and Martin, M.A.  (2001)  HIV-1 replication.  In Lentiviral Vectors for Gene Therapy, Chapter 2 (G.L. Buchschacher, ed.), Landes Bioscience, Georgetown, TX, pp. 13-33.

Ono, A., and Freed, E.O.  (2001)  Role of matrix in HIV-1 replication.  Rec. Res. Dev. Virol. 3: 483-494.

Ono, A., and Freed, E.O.  (2001)  Plasma membrane rafts play a critical role in HIV-1 assembly and release.  Proc. Natl. Acad. Sci. USA 98: 13925-13930.
Abstract      Full-text PDF from NIH Public Access     Supporting information
PMID 11717449; PMCID PMC61143

Tang, Y., Murakami, T., Agresta, B.E., Campbell, S., Freed, E.O., and Levin, J.G.  (2001)  Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells.  J. Virol. 75: 9357-9366.
Abstract     Full-text PDF from NIH Public Access
PMID 11533199; PMCID PMC114504

Banks, W.A., Freed, E.O., Wolf, K.M., Robinson, S.M., Franko, M., and Kumar, V.B.  (2001)  Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: Role of envelope proteins and adsorptive endocytosis.  J. Virol. 75: 4681-4691.
Abstract     Full-text PDF from NIH Public Access
PMID 11312339; PMCID PMC114222

Freed, E.O., and Martin, M.A.  (2001)  HIVs and their replication.  In Fields Virology, 4th Edition (D.M. Knipe and P.M. Howley, eds.), Lippincott, Williams, and Wilkins, Philadelphia, pp. 1971-2041.

Freed, E.O., and Martin, M.A.  (2001)  HIVs and their replication.  In Fundamental Virology, 4th Edition, Chapter 28 (D.M. Knipe and P.M. Howley, eds.), Lippincott, Williams, and Wilkins, Philadelphia, pp. 913-983.

Freed, E.O., and Martin, M.A.  (2001)  The molecular and biological properties of the human immunodeficiency virus.  In The Molecular Basis of Blood Diseases, 3rd Edition, Chapter 27 (G. Stamatoyannopoulos, P.W. Majerus, R.M. Perlmutter, and H. Varmus, eds.), W.B. Saunders, Philadelphia, pp. 861-915.

Halvas, E.K., Svarovskaia, E.S., Freed, E.O., and Pathak, V.K.  (2000)  Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidine.  J. Virol. 74: 6669-6674.
Abstract     Full-text PDF from NIH Public Access
PMID 10864683; PMCID PMC112179

Ono, A., Demirov, D., and Freed, E.O.  (2000)  Relationship between human immunodeficiency virus type 1 Gag multimerization and membrane binding.  J. Virol. 74: 5142-5150.
Abstract     Full-text PDF from NIH Public Access
PMID 10799589; PMCID PMC110867

Murakami, T., and Freed, E.O.  (2000)  Genetic evidence for an interaction between human immunodeficiency virus type 1 matrix and alpha-helix 2 of the gp41 cytoplasmic tail.  J. Virol. 74: 3548-3554.
Abstract     Full-text PDF from NIH Public Access
PMID 10729129; PMCID PMC111863

Ono, A., Orenstein, J.M., and Freed, E.O.  (2000)  Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly.  J. Virol. 74: 2855-2866.
Abstract     Full-text PDF from NIH Public Access
PMID 10684302; PMCID PMC111776

Murakami, T., and Freed, E.O.  (2000)  The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions.  Proc. Natl. Acad. Sci. USA 97: 343-348.
Abstract     Full-text PDF from NIH Public Access
PMID 10618420; PMCID PMC26665

Tang, Y., Winkler, U., Freed, E.O., Torrey, T.A., Kim, W., Li, H., Goff, S.P., and Morse, H.C. III.  (1999)  Cellular motor protein KIF-4 associates with retroviral Gag.  J. Virol. 73: 10508-10513.
Abstract     Full-text PDF from NIH Public Access
PMID 10559369; PMCID PMC113106

Kiernan, R.E., Ono, A., and Freed, E.O.  (1999)  Reversion of a human immunodeficiency virus type 1 matrix mutation affecting Gag membrane binding, endogenous reverse transcriptase activity, and virus infectivity.  J. Virol. 73: 4728-4737.
Abstract     Full-text PDF from NIH Public Access
PMID 10233933; PMCID PMC112515

Ono, A., and Freed, E.O.  (1999)  Binding of human immunodeficiency virus type 1 Gag to membrane: role of the matrix amino terminus.  J. Virol. 73: 4136-4144.
Abstract     Full-text PDF from NIH Public Access
PMID 10196310; PMCID PMC104193

Kiernan, R.E., and Freed, E.O.  (1998)  Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: Transdominant inhibition by matrix mutations.  J. Virol. 72: 9621-9627.
Abstract     Full-text PDF from NIH Public Access
PMID 9811695; PMCID PMC110471

Freed, E.O.  (1998)  HIV-1 gag proteins: Diverse functions in the virus life cycle.  Virology 251: 1-15.
Abstract     Full-text PDF from publisher     PMID 9813197

Kiernan, R.E., Ono, A., Englund, G., and Freed, E.O.  (1998)  Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle.  J. Virol. 72: 4116-4126.
Abstract     Full-text PDF from NIH Public Access
PMID 9557701; PMCID PMC109641

Ono, A., Huang, M., and Freed, E.O.  (1997)  Characterization of human immunodeficiency virus type 1 matrix revertants: effects on virus assembly, Gag processing, and Env incorporation into virions.  J. Virol. 71: 4409-4418.
Abstract     Full-text PDF from NIH Public Access
PMID 9151831; PMCID PMC191659

Freed, E.O.  (1997)  Acquired immune deficiency syndrome – Virology.  In The Encyclopedia of Human Biology, 2nd Edition, Volume I, Academic Press, Inc., pp. 49-55.

Freed, E.O., Englund, G., Maldarelli, F., and Martin, M.A.  (1997)  Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.  Cell 88: 171-174.
PubMed citation     Full-text PDF from publisher     PMID 8523546

Freed, E.O.  (1997)  Retroviruses.  In The Encyclopedia of Cancer, Volume III, Academic Press, Inc., pp. 1585-1590.

Willey, R.L., Shibata, R., Freed, E.O., Cho, M.W., and Martin, M.A.  (1996)  Differential glycosylation, virion incorporation, and sensitivity to neutralizing antibodies of human immunodeficiency virus type 1 envelope produced from infected primary T-lymphocyte and macrophage cultures.  J. Virol. 70: 6431-6436.
Abstract     Full-text PDF from NIH Public Access
PMID 8709276; PMCID PMC190674

Delahunty, M.D., Rhee, I., Freed, E.O., Engelman, A., and Bonifacino, J.S.  (1996)  Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.  Virology 218: 94-102.
Abstract     Full-text PDF from publisher     PMID 8615045

Freed, E.O., and Martin, M.A.  (1996)  Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions.  J. Virol. 70: 341-351.
Abstract     Full-text PDF from NIH Public Access
PMID 8523546; PMCID PMC189823

Freed, E.O., and Martin, M.A.  (1995)  Characterization of HIV-1 matrix and gp41 domains involved in Env incorporation into virions.  In Retroviruses of Human AIDS and Related Animal Diseases, Cent Garde Symposium, Paris, pp. 111-116.

Huang, M., Orenstein, J.M., Martin, M.A., and Freed, E.O.  (1995)  p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease.  J. Virol. 69: 6810-6818.
Abstract     Full-text PDF from NIH Public Access
PMID 7474093; PMCID PMC189593

Freed, E.O., and Martin, M.A.  (1995)  The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection.  J. Biol. Chem. 270: 23883-23886.
PubMed citation     Full-text PDF from publisher     PMID 7592573

Freed, E.O., Englund, G., and Martin, M.A.  (1995)  Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.  J. Virol. 69: 3949-3954.
Abstract     Full-text PDF from NIH Public Access
PMID 7745752; PMCID PMC189124

Englund, G., Theodore, T.S., Freed, E.O., Engelman, A., and Martin, M.A.  (1995)  Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.  J. Virol. 69: 3216-3219.
Abstract     Full-text PDF from NIH Public Access
PMID 7707554; PMCID PMC189028

Freed, E.O., and Martin, M.A.  (1995)  Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix.  J. Virol. 69: 1984-1989.
Abstract     Full-text PDF from NIH Public Access
PMID 7853546; PMCID PMC188822

Buchschacher, G.L., Jr., Freed, E.O., and Panganiban, A.T.  (1995)  Effects of second-site mutations on dominant interference by a human immunodeficiency virus type 1 envelope glycoprotein mutant.  J. Virol. 69: 1344-1348.
Abstract     Full-text PDF from NIH Public Access
PMID 7815519; PMCID PMC188718

Freed, E.O., Orenstein, J.M., Buckler-White, A.J., and Martin, M.A.  (1994)  Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production.  J. Virol. 68: 5311-5320.
Abstract     Full-text PDF from NIH Public Access
PMID 8035531; PMCID PMC236481

Freed, E.O., and Martin, M.A.  (1994)  HIV-1 infection of non-dividing cells.  Nature 369: 107-108.
PubMed citation     Full-text PDF from publisher     PMID 8192816

Freed, E.O., and Martin, M.A.  (1994)  Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.  J. Virol. 68: 2503-2512.
Abstract     Full-text PDF from NIH Public Access
PMID 8139032; PMCID PMC236728

Buchschacher, G.L., Jr., Freed, E.O., and Panganiban, A.T.  (1992)  Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus.  Hum. Gene Ther. 3: 391-397.
Abstract     Full-text PDF from publisher     PMID 1356022

Chiou, S.-H., Freed, E.O., Panganiban, A.T., and Kenealy, W.R.  (1992)  Studies on the role of the V3 loop in human immunodeficiency virus type 1 envelope glycoprotein function.  AIDS Res. Hum. Retroviruses. 8: 1611-1618.
Abstract     Full-text PDF from publisher     PMID 1457207

Freed, E.O., and Myers, D.J.  (1992)  Identification and characterization of fusion and processing domains of the human immunodeficiency virus type 2 envelope glycoprotein.  J. Virol. 66: 5472-5478.
Abstract     Full-text PDF from NIH Public Access
PMID 1501283; PMCID PMC289104

Delwart, E.L., Buchschacher, G.L., Jr., Freed, E.O., and Panganiban, A.T.  (1992)  Analysis of HIV-1 envelope mutants and pseudotyping of replication-defective HIV-1 vectors by genetic complementation.  AIDS Res. Hum. Retroviruses 8: 1669-1677.
Abstract     Full-text PDF from publisher     PMID 1457211

Freed, E.O., Delwart, E.L., Buchschacher, G.L., Jr., and Panganiban, A.T.  (1992)  A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity.  Proc. Natl. Acad. Sci. USA 89: 70-74.
Abstract     Full-text PDF from NIH Public Access
PMID 1729720; PMCID PMC48177

Freed, E.O., and Risser, R.  (1991)  Identification of conserved residues in the human immunodeficiency virus type 1 principal neutralizing determinant that are involved in fusion.  AIDS Res. Hum. Retroviruses 7: 807-811.
Abstract     Full-text PDF from publisher     PMID 1720627

Freed, E.O., Myers, D.J., and Risser, R.  (1991)  Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain.  J. Virol. 65: 190-194.
Abstract     Full-text PDF from NIH Public Access
PMID 1985197; PMCID PMC240504

Freed, E.O., Myers, D.J., and Risser, R.  (1990)  Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Proc. Natl. Acad. Sci. USA 87: 4650-4654.
Abstract     Full-text PDF from NIH Public Access
PMID 2191297; PMCID PMC54174

Freed, E.O., and Risser, R.  (1990)  The role of the HIV envelope glycoproteins in cell fusion and the pathogenesis of AIDS.  Bull. Inst. Pasteur 88: 73-110.

Freed, E.O., Myers, D.J., and Risser, R.  (1989)  Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160.  J. Virol. 63: 4670-4675.
Abstract     Full-text PDF from NIH Public Access
PMID 2677400; PMCID PMC251101

Freed, E.O., and Risser, R.  (1987)  The role of envelope glycoprotein processing in murine leukemia virus infection.  J. Virol. 61: 2852-2856.
Abstract     Full-text PDF from NIH Public Access
PMID 3039173; PMCID PMC255803

Shalloway, D., Johnson, P.J., Freed, E.O., Coulter, D., and Flood, W.A., Jr.  (1987)  Transformation of NIH 3T3 cells by cotransfection with c-src and nuclear oncogenes.  Mol. Cell. Biol. 7: 3582-3590.
Abstract     Full-text PDF from NIH Public Access
PMID 2446117; PMCID PMC368012



Last modified: 25 July 2017


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