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Publications


PubMed summary

ORCID ID 0000-0002-9176-4377


Selected Key Publications

Maldarelli, F., Wu, X., Su, L., Simonetti, F.R., Shao, W., Hill, S., Spindler, J., Ferris, A.L., Mellors, J.W., Kearney, M.F., Coffin, J.M., and Hughes, S.H.  (2014)  Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.  Science 345: 179-183.
Abstract     Full-text PDF     Supplementary material     PMID 24968937; PMCID PMC4262401
DOI 10.1126/science.1254194

Related articles:

Cohen, J.  (2014)  News & Analysis — Cancer genes help HIV persist, complicating cure efforts.  Science 343: 1188.

Margolis, D., and Bushman, F.  (2014)  Perspectives — Persistence by proliferation?  Science 345: 143-144.

Saey, T.H.  (2014)  HIV hides in growth-promoting genes.  ScienceNews, 26 June 2014.

Baum, C.  (2014)  Editorial — Data vs. dogma: HIV-1 integrations driving clonal selection.  Mol. Ther. 22: 1557-1558.

Damania, B.  (2014)  F1000Prime recommendation of [Maldarelli F et al., Science 2014, 345(6193):179-83].  F1000Prime, 21 Jul 2014; DOI 10.3410/f.718470203.793497467.

National Cancer Institute press release, 26 June 2014:  NCI News Note — Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.

Cell "Leading Edge Select" feature, 31 July 2014:  Opening the HIV mystery box — The right spot to integrate and persist.  Cell 158: 469, 471.

National Cancer Institute, Center for Cancer Research, News | headlines, July 2014:  HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells.

National Cancer Institute at Frederick Poster feature, 8 August 2014:  Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.

Ferris, A.L., Wu, X., Hughes, C.M., Stewart, C., Smith, S.J., Milne, T.A., Wang, G.G., Shun, M.-C., Allis, C.D., Engelman, A., and Hughes, S.H.  (2010)  Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.  Proc. Natl. Acad. Sci. USA 107: 3135-3140.
Abstract     Full-text PDF     Supporting information
PMID 20133638; PMCID PMC2840313     DOI 10.1073/pnas.0914142107

Boyer, P.L., Sarafianos, S.G., Arnold, E., and Hughes, S.H.  (2001)  Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.  J. Virol. 75: 4832-4842.
Abstract     Full-text PDF     PMID 11312355; PMCID PMC114238
DOI 10.1128/JVI.75.10.4832-4842.2001

Federspiel, M.J., Bates, P., Young, J.A., Varmus, H.E., and Hughes, S.H.  (1994)  A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors.  Proc. Natl. Acad. Sci. USA 91: 11241-11245.
Abstract     Full-text PDF     PMID 7972042; PMCID PMC45203

Jacobo-Molina, A., Ding, J., Nanni, R.G., Clark, A.D., Jr., Lu, X., Tantillo, C., Williams, R.L., Kamer, G., Ferris, A.L., Clark, P., Hizi, A., Hughes, S.H., and Arnold, E.  (1993)  Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Ĺ resolution shows bent DNA.  Proc. Natl. Acad. Sci. USA 90: 6320-6324.
Abstract     Full-text PDF      PMID 7687065; PMCID PMC46920


Recent Publications

Smith, S.J., Zhao, X.Z., Burke, T.R., Jr., and Hughes, S.H.  (2018)  HIV-1 integrase inhibitors that are broadly effective against drug-resistant mutants.  Antimicrob. Agents Chemother. 62: e01035-18.
Abstract     Full-text PDF     PMID 29987149; PMCID PMC6125528
DOI 10.1128/AAC.01035-18

Boyer, P.L., Smith, S.J., Zhao, X.Z., Das, K., Gruber, K., Arnold, E., Burke, T.R., Jr., and Hughes, S.H.  (2018)  Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase.  J. Virol. 92: e00381-18.
Abstract     Full-text PDF     PMID 29643235; PMCID PMC6002700
DOI 10.1128/JVI.02203-17

Smith, S.J., Zhao, X.Z., Burke, T.R., Jr., and Hughes, S.H.  (2018)  Efficacies of cabotegravir and bictegravir against drug-resistant HIV-1 integrase mutants.  Retrovirology 15: 37.
Abstract     Full-text PDF     PMID 29769116; PMCID PMC5956922
DOI 10.1186/s12977-018-0420-7

Varadarajan, J., McWilliams, M.J., Mott, B.T., Thomas, C.J., Smith, S.J., and Hughes, S.H.  (2016)  Drug resistant integrase mutants cause aberrant HIV integrations.  Retrovirology 13(1): 71.
Abstract     Full-text PDF     PMID 27682062; PMCID PMC5041404
DOI 10.1186/s12977-016-0305-6

Smith, S.J., Pauly, G.T., Akram, A., Melody, K., Ambrose, Z., Schneider, J.P., and Hughes, S.H.  (2016)  Rilpivirine and doravirine have complementary efficacies against NNRTI-resistant HIV-1 mutants.  J. Acquir. Immune Defic. Syndr. 72: 485-491.
Abstract     Full-text PDF     Supplemental information
PMID 27124362; PMCID PMC4942337     DOI 10.1097/QAI.0000000000001031

Hughes, S.H., and Coffin, J.M.  (2016)  What integration sites tell us about HIV persistence.  Cell Host Microbe 19: 588-598.
Abstract     Full-text PDF     PMID 27173927; PMCID PMC4900157
DOI 10.1016/j.chom.2016.04.010

Smith, S.J., Pauly, G.T., Akram, A., Melody, K., Raj, G., Maloney, D.J., Ambrose, Z., Thomas, C.J., Schneider, J.T., and Hughes, S.H.  (2016)  Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.  Retrovirology 13: 11.
Abstract     Full-text PDF     Additional files     PMID 26880034; PMCID PMC4754833
DOI 10.1186/s12977-016-0244-2

Simonetti, F.R., Sobolewski, M.D., Fyne, E., Shao, W., Spindler, J., Hattori, J., Anderson, E.M., Watters, S.A., Hill, S., Wu, X., Wells, D., Su, L., Luke, B.T., Halvas, E.K., Besson, G., Penrose, K.J., Yang, Z., Kwan, R.W., Van Waes, C., Uldrick, T., Citrin, D., Kovacs, J., Polis, M.A., Rehm, C.A., Gorelick, R., Piatak, M., Keele, B.F., Kearney, M.F., Coffin, J.M., Hughes, S.H., Mellors, J.W., and Maldarelli, F.  (2016)  Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.  Proc. Natl. Acad. Sci. USA 113: 1883-1888.
Abstract     Full-text PDF     Supporting information     PMID 26858442; PMCID PMC4763755
DOI 10.1073/pnas.1522675113

Related article:

Kim, M., and R.F. Siliciano.  (2016)  Commentary: Reservoir expansion by T-cell proliferation may be another barrier to curing HIV infection.  Proc. Natl. Acad. Sci. USA 113: 1692-1694.

Skaar, J.R., Ferris, A.L., Wu, X., Saraf, A., Khanna, K.K., Florens, L., Washburn, M.P., Hughes, S.H., and Pagano, M.  (2015)  The Integrator complex controls the termination of transcription at diverse classes of gene targets.  Cell Res. 25: 288-305.
Abstract     Full-text PDF     Supplementary information
PMID 25675981; PMCID PMC4349240     DOI 10.1038/cr.2015.19

Maldarelli, F., Wu, X., Su, L., Simonetti, F.R., Shao, W., Hill, S., Spindler, J., Ferris, A.L., Mellors, J.W., Kearney, M.F., Coffin, J.M., and Hughes, S.H.  (2014)  Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.  Science 345: 179-183.
Abstract     Full-text PDF     Supplementary material     PMID 24968937; PMCID PMC4262401
DOI 10.1126/science.1254194

Related articles:

Cohen, J.  (2014)  News & Analysis — Cancer genes help HIV persist, complicating cure efforts.  Science 343: 1188.

Margolis, D., and Bushman, F.  (2014)  Perspectives — Persistence by proliferation?  Science 345: 143-144.

Saey, T.H.  (2014)  HIV hides in growth-promoting genes.  ScienceNews, 26 June 2014.

Baum, C.  (2014)  Editorial — Data vs. dogma: HIV-1 integrations driving clonal selection.  Mol. Ther. 22: 1557-1558.

Damania, B.  (2014)  F1000Prime recommendation of [Maldarelli F et al., Science 2014, 345(6193):179-83].  F1000Prime, 21 Jul 2014; DOI 10.3410/f.718470203.793497467.

National Cancer Institute press release, 26 June 2014:  NCI News Note — Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.

Cell "Leading Edge Select" feature, 31 July 2014:  Opening the HIV mystery box — The right spot to integrate and persist.  Cell 158: 469, 471.

National Cancer Institute, Center for Cancer Research, News | headlines, July 2014:  HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells.

National Cancer Institute at Frederick Poster feature, 8 August 2014:  Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.


Last modified: 25 April 2019


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