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Publications


PubMed summary


Selected Key Publications

Van Zyl, G.U., Katusiime, M.G., Wiegand, A., McManus, W.R., Bale, M.J., Halvas, E.K., Luke, B., Boltz, V.F., Spindler, J., Laughton, B., Engelbrecht, S., Coffin, J.M., Cotton, M.F., Shao, W., Mellors, J.W., and Kearney, M.F.  (2017)  No evidence of HIV replication in children on antiretroviral therapy.  J. Clin. Invest. 127: 3827-3834.
Abstract     Full-text PDF     PMID 28891813; PMCID 5617669
DOI 10.1172/JCI94582

Wiegand, A., Spindler, J., Hong, F.F., Shao, W., Cyktor, J.C., Cillo, A.R., Halvas, E.K., Coffin, J.M., Mellors, J.W., and Kearney, M.F.  (2017)  Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.  Proc. Natl. Acad. Sci. USA 114: E3659-E3668.
Abstract     Full-text PDF     Supporting information     PMID 28416661; PMCID PMC5422779
DOI 10.1073/pnas.1617961114

Kearney, M.F., Wiegand, A., Shao, W., Coffin, J.M., Mellors, J.W., Lederman, M., Gandhi, R.T., Keele, B.F., and Li, J.Z.  (2016)  Origin of rebound plasma HIV includes cells with identical proviruses that are transcriptionally active before stopping antiretroviral therapy.  J. Virol. 90: 1369-1376.
Abstract     Full-text PDF     PMID 26647281; PMCID PMC4719635
DOI 10.1128/JVI.02139-15

Kearney, M.F., Anderson, E.M., Coomer, C., Smith, L., Shao, W., Johnson, N., Kline, C., Spindler, J., Mellors, J.W., Coffin, J.M., and Ambrose, Z.  (2015)  Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy.  Retrovirology 12: 93.
Abstract     Full-text PDF     PMID 26559632; PMCID PMC4642622
DOI 10.1186/s12977-015-0212-2

Kearney, M.F., Spindler, J., Shao, W., Yu, S., Anderson, E.M., O'Shea, A., Rehm, C., Poethke, C., Kovacs, N., Mellors, J.W., Coffin, J.M., and Maldarelli, F.  (2014)  Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy.  PLoS Pathog. 10(3): e1004010.
Abstract     Full-text PDF     Supporting information     PMID 24651464; PMCID PMC3961343
DOI 10.1371/journal.ppat.1004010


Recent Publications

Kearney, M.F., Spindler, J., Wiegand, A., Shao, W., Haubrich, R., Riddler, S., Lalama, C.M., Hughes, M.D., Coffin, J.M., and Mellors, J.W.  (2018)  Lower pre-ART intra-participant HIV-1 pol diversity may not be associated with virologic failure in adults.  PLoS ONE 13(1): e0190438.
Abstract     Full-text PDF     Supporting information     PMID 29370196; PMCID 5784902
DOI 10.1371/journal.pone.0190438

Van Zyl, G.U., Katusiime, M.G., Wiegand, A., McManus, W.R., Bale, M.J., Halvas, E.K., Luke, B., Boltz, V.F., Spindler, J., Laughton, B., Engelbrecht, S., Coffin, J.M., Cotton, M.F., Shao, W., Mellors, J.W., and Kearney, M.F.  (2017)  No evidence of HIV replication in children on antiretroviral therapy.  J. Clin. Invest. 127: 3827-3834.
Abstract     Full-text PDF     PMID 28891813; PMCID 5617669
DOI 10.1172/JCI94582

Wiegand, A., Spindler, J., Hong, F.F., Shao, W., Cyktor, J.C., Cillo, A.R., Halvas, E.K., Coffin, J.M., Mellors, J.W., and Kearney, M.F.  (2017)  Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.  Proc. Natl. Acad. Sci. USA 114: E3659-E3668.
Abstract     Full-text PDF     Supporting information     PMID 28416661; PMCID PMC5422779
DOI 10.1073/pnas.1617961114

Kearney, M.F., Wiegand, A., Shao, W., McManus, W.R., Bale, M., Luke, B., Maldarelli, F., Mellors, J.W., and Coffin, J.M.  (2017)  Perspectives: Ongoing HIV replication during ART reconsidered.  Open Forum Infect. Dis. 4(3): 1-5.
Abstract     Full-text PDF     Supplementary data     PMID 30310821; PMCID PMC6172598
DOI 10.1093/ofid/ofx173

Boltz, V.F., Rausch, J., Shao, W., Hattori, J., Luke, B., Maldarelli, F., Mellors, J.W., Kearney, M.F., and Coffin, J.M.  (2016)  Ultrasensitive single-genome sequencing: Accurate, targeted, next generation sequencing of HIV-1 RNA.  Retrovirology 13: 87.
Abstract     Full-text PDF     PMID 27998286; PMCID PMC5175307
DOI 10.1186/s12977-016-0321-6

Kearney, M.F., Wiegand, A., Shao, W., Coffin, J.M., Mellors, J.W., Lederman, M., Gandhi, R.T., Keele, B.F., and Li, J.Z.  (2016)  Origin of rebound plasma HIV includes cells with identical proviruses that are transcriptionally active before stopping antiretroviral therapy.  J. Virol. 90: 1369-1376.
Abstract     Full-text PDF     PMID 26647281; PMCID PMC4719635
DOI 10.1128/JVI.02139-15

Kearney, M.F., Anderson, E.M., Coomer, C., Smith, L., Shao, W., Johnson, N., Kline, C., Spindler, J., Mellors, J.W., Coffin, J.M., and Ambrose, Z.  (2015)  Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy.  Retrovirology 12: 93.
Abstract     Full-text PDF     PMID 26559632; PMCID PMC4642622
DOI 10.1186/s12977-015-0212-2

Maldarelli, F., Wu, X., Su, L., Simonetti, F.R., Shao, W., Hill, S., Spindler, J., Ferris, A.L., Mellors, J.W., Kearney, M.F., Coffin, J.M., and Hughes, S.H.  (2014)  Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.  Science 345: 179-183.
Abstract     Full-text PDF     Supplementary material     PMID 24968937; PMCID PMC4262401
DOI 10.1126/science.1254194

Related articles:

Cohen, J.  (2014)  News & Analysis — Cancer genes help HIV persist, complicating cure efforts.  Science 343: 1188.

Margolis, D., and Bushman, F.  (2014)  Perspectives — Persistence by proliferation?  Science 345: 143-144.

Saey, T.H.  (2014)  HIV hides in growth-promoting genes.  ScienceNews, 26 June 2014.

Baum, C.  (2014)  Editorial — Data vs. dogma: HIV-1 integrations driving clonal selection.  Mol. Ther. 22: 1557-1558.

Damania, B.  (2014)  F1000Prime recommendation of [Maldarelli F et al., Science 2014, 345(6193):179-83].  F1000Prime, 21 Jul 2014; DOI 10.3410/f.718470203.793497467.

National Cancer Institute press release, 26 June 2014:  NCI News Note — Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.

Cell "Leading Edge Select" feature, 31 July 2014:  Opening the HIV mystery box — The right spot to integrate and persist.  Cell 158: 469, 471.

National Cancer Institute, Center for Cancer Research, News | headlines, July 2014:  HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells.

National Cancer Institute at Frederick Poster feature, 8 August 2014:  Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells.

Kearney, M.F., Spindler, J., Shao, W., Yu, S., Anderson, E.M., O'Shea, A., Rehm, C., Poethke, C., Kovacs, N., Mellors, J.W., Coffin, J.M., and Maldarelli, F.  (2014)  Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy.  PLoS Pathog. 10(3): e1004010.
Abstract     Full-text PDF     Supporting information     PMID 24651464; PMCID PMC3961343
DOI 10.1371/journal.ppat.1004010

Maldarelli, F., Kearney, M., Palmer, S., Stephens, R., Mican, J., Polis, M.A., Davey, R.T., Kovacs, J., Shao, W., Rock-Kress, D., Metcalf, J.A., Rehm, C., Greer, S.E., Lucey, D.L., Danley, K., Alter, H., Mellors, J.W., and Coffin, J.M.  (2013)  HIV populations are large and accumulate high genetic diversity in a nonlinear fashion.  J. Virol. 87: 10313-10323.
Abstract     Full-text PDF     PMID 23678164; PMCID PMC3754011
DOI 10.1128/JVI.01225-12


Last modified: 10 June 2019


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