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Full PubMed List of Publications by F. Maldarelli


Selected Publications

Winchester, N.E., Maldarelli, F., Mejia, Y., Dee, N., Dewar, R., Laidlaw, E., Kuriakose, S.S., Stoll, P., Proschan, M., Lane, H.C., Pau, A.K.  (2019)  8-day inpatient directly observed therapy for ART failure: A tool for preventing unnecessary ART changes and optimizing adherence support.  Clin. Infect. Dis., in press (Jul 11 Epub ahead of print).
Abstract     Full-text PDF     PMID 31217357     DOI 10.1093/cid/ciz590

Coffin, J.M., Wells, D., Zerbato, J.M., Kuruc, J.D., Guo, S., Luke, B.T., Eron, J.J., Bale, M., Spindler, J., Simonetti, F.R., Hill, S., Kearney, M.F., Maldarelli, F., Wu, X., Mellors, J.W., and Hughes, S.H.  (2019)  Clones of infected cells arise early in HIV infected individuals.  JCI Insight 4: e128432.
Abstract     Full-text PDF     PMID 31217357     DOI 10.1172/jci.insight.128432

Related video:

Coffin, J., and Hughes, S.H.  Author's Take — Persistence of early arising clones of HIV-infected cells in patients.  JCI Insight, published July 3, 2019.

Fennessey, C.M., Camus, C., Immonen, T.T., Reid, C., Maldarelli, F., Lifson, J.D., and Keele, B.F. (2019) Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo. Retrovirology 16(1): 11.
Abstract     Full-text PDF     PMID 30947720     DOI 10.1186/s12977-019-0473-2

Gibson, K.M., Steiner, M.C., Kassaye, S., Maldarelli, F., Grossman, Z., Pérez-Losada, M., and Crandall, K.A. (2019) A 28-year history of HIV-1 drug resistance and transmission in Washington, DC. Front. Microbiol. 10: 369.
Abstract     Full-text PDF     PMID 30906285; PMCID PMC6418020
DOI 10.3389/fmicb.2019.00369

Reid, E.G., Looney, D., Maldarelli, F., Noy, A., Henry, D., Aboulafia, D., Ramos, J.C., Sparano, J., Ambinder, R.F., Lee, J., Cesarman, E., Yahyaei, S., Mitsuyasu, R., Wachsman, W., for the AIDS Malignancy Consortium. (2018) Safety and efficacy of an oncolytic viral strategy using bortezomib with ICE/R in relapsed/refractory HIV-positive lymphomas. Blood Adv. 2: 3618-3626.
Abstract     Full-text PDF from NIH Public Access     PMID 30573564

George, J.M., Kuriakose, S.S., Dee, N., Stoll, P., Lalani, T., Dewar, R., Khan, M.A., Rehman, M.T., Grossman, Z., Maldarelli, F., and Pau, A.K. (2018) Rapid development of high-level resistance to dolutegravir with emergence of T97A mutation in 2 treatment-experienced individuals with baseline partial sensitivity to dolutegravir. Open Forum Infect. Dis. 5(10): ofy221.
Abstract     Full-text PDF from NIH Public Access     PMID 30568974

Pastrana, D.V., Peretti, A., Welch, N.L., Borgogna, C., Olivero, C., Badolato, R., Notarangelo, L.D., Gariglio, M., FitzGerald, P.C., McIntosh, C.E., Reeves, J., Starrett, G.J., Bliskovsky, V., Velez, D., Brownell, I., Yarchoan, R., Wyvill, K.M., Uldrick, T.S., Maldarelli, F., Lisco, A., Sereti, I., Gonzalez, C.M., Androphy, E.J., McBride, A.A., Van Doorslaer, K., Garcia, F., Dvoretzky, I., Liu, J.S., Han, J., Murphy, P.M., McDermott, D.H., and Buck, C.B. (2018) Metagenomic discovery of 83 new human papillomavirus types in patients with immunodeficiency. mSphere 3(6): e00645-18.
Abstract     Full-text PDF from publisher     PMID 30541782

Anderson, E.M., and Maldarelli, F. (2018) Quantification of HIV DNA using droplet digital PCR techniques. Curr. Protoc. Microbiol. 51: e62.
Abstract     Full-text PDF from publisher     PMID 30253074

Anderson, E.M., and Maldarelli, F. (2018) The role of integration and clonal expansion in HIV infection: Live long and prosper. Retrovirology 15: 71.
Abstract     Full-text PDF from publisher     PMID 30352600

Grossman, Z., Rico, S., Cone, K., Shao, W., Rehm, C., Jones, S., Bozzi, G., Dean, S., Dewar, R., Rehman, T., Purdy, J., Hadigan, C., Pau, A.K., and Maldarelli, F. (2018) Early presence of HIV-1 subtype C in Washington, D.C. AIDS Res. Hum. Retroviruses 34: 680-684.
Abstract     Full-text PDF from publisher     Supplemental material     PMID 29936863

Kearney, M.F., Wiegand, A., Shao, W., McManus, W.R., Bale, M., Luke, B., Maldarelli, F., Mellors, J.W., and Coffin, J.M. (2017) Perspectives: Ongoing HIV replication during ART reconsidered. Open Forum Infect. Dis. 4(3): 1-5.
Abstract     Full-text PDF from publisher     Supplementary data

Brooks, K.M., Garrett, K.L., Kuriakose, S.S., George, J.M., Balba, G., Bailey, B., Anderson, M., Lane, H.C., Maldarelli, F., and Pau, A.K. (2017) Decreased absorption of dolutegravir and tenofovir disoproxil fumarate, but not emtricitabine, in an HIV-infected patient following oral and jejunostomy-tube administration. Pharmacotherapy 37(8): e82-e89.
Abstract     Full-text PDF from publisher     PMID 28556353

Paredes, R., Tzou, P.L., van Zyl, G., Barrow, G., Camacho, R., Carmona, S., Grant, P.M., Gupta, R.K., Hamers, R.L., Harrigan, P.R., Jordan, M.R., Kantor, R., Katzenstein, D.A., Kuritzkes, D.R., Maldarelli, F., Otelea, D., Wallis, C.L., Schapiro, J.M., and Shafer, R.W. (2017) Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation. PLoS One 12(7):e0181357.
Abstract     Full-text PDF from publisher     Supporting information
PMID 28753637

Boltz, V.F., Rausch, J., Shao, W., Hattori, J., Luke, B., Maldarelli, F., Mellors, J.W., Kearney, M.F., and Coffin, J.M. (2016) Ultrasensitive single-genome sequencing: Accurate, targeted, next generation sequencing of HIV-1 RNA. Retrovirology 13: 87.     [Abstract]
[Full-text PDF (3794 K) from publisher]     [PMID: 27998286]

Polizzotto, M.N., Uldrick, T.S., Wyvill, K.M., Aleman, K., Peer, C.J., Bevans, M., Sereti, I., Maldarelli, F., Whitby, D., Marshall, V., Goncalves, P.H., Khetani, V., Figg, W.D., Steinberg, S.M., Zeldis, J.B., and Yarchoan, R. (2016) Pomalidomide for symptomatic Kaposi's sarcoma in people with and without HIV infection: A phase I/II study. J. Clin. Oncol. 34: 4125-4131.
[Abstract]     [Full-text PDF (674 K) from publisher]     [PMID: 27863194]

Mikula, J.M., Manion, M.M., Maldarelli, F., Suarez, L.M., Norman-Wheeler, J.F., Ober, A.G., Dewar, R.L., Kopp, J.B., Lane, H.C., and Pau, A.K. (2016) Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy. Antivir Ther. 21: 553-558.     [Abstract]
[Full-text PDF (187 K) from publisher]     [PMID: 26954372]

Desimmie, B.A., Burdick, R.C., Izumi, T., Doi, H., Shao, W., Alvord, W.G., Sato, K., Koyanagi, Y., Jones, S., Wilson, E., Hill, S., Maldarelli, F., Hu, W.-S., and Pathak, V.K. (2016) APOBEC3 proteins can copackage and comutate HIV-1 genomes. Nucleic Acids Res. 44: 7848-7865.
[Abstract]     [Full-text PDF (1734 K) from NIH Public Access]
[Supplementary data]     [PMID: 27439715; PMCID: PMC5027510 ]

Kassaye, S.G., Grossman, Z., Balamane, M., Johnston-White, B., Liu, C., Kumar, P., Young, M., Sneller, M.C., Sereti, I., Dewar, R., Rehm, C., Meyer, W. 3rd, Shafer, R., Katzenstein, D., and Maldarelli, F. (2016) Transmitted HIV drug resistance high and longstanding in metropolitan Washington, D.C. Clin. Infect. Dis. 63: 836-843.     [Abstract]
[Full-text PDF (663 K) from publisher]     [Supplementary data]     [PMID: 27307507]

Boritz, E.A., Darko, S., Swaszek, L., Wolf, G., Wells, D., Wu, X., Henry, A.R., Laboune, F., Hu, J., Ambrozak, D., Hughes, M.S., Hoh, R., Casazza, J.P., Vostal, A., Bunis, D., Nganou-Makamdop, K., Lee, J.S., Migueles, S.A., Koup, R.A., Connors, M., Moir, S., Schacker, T., Maldarelli, F., Hughes, S.H., Deeks, S.G., and Douek, D.C. (2016) Multiple origins of virus persistence during natural control of HIV infection. Cell 166: 1004-1015.
[Abstract]     [Full-text PDF (1631 K) from publisher]     [PMID: 27453467]

Watters, S.A., Mlcochova, P., Maldarelli, F., Goonetilleke, N., Pillay, D., and Gupta, R.K. (2016) Sequential CCR5-tropic HIV-1 reactivation from distinct cellular reservoirs following perturbation of elite control. PLoS ONE 11(7):e0158854.
[Abstract]     [Full-text PDF (536 K) from NIH Public Access]
[PMID: 27403738; PMCID: PMC4942039]

Shao, W., Shan, J., Kearney, M.F., Wu, X., Maldarelli, F., Mellors, J.W., Luke, B., Coffin, J.M., and Hughes, S.H. (2016) Retrovirus Integration Database (RID): A public database for retroviral insertion sites into host genomes. Retrovirology 13: 47.     [Abstract]
[Full-text PDF (2863 K) from publisher]     [PMID: 27377064]

Simonetti, F.R., Sobolewski, M.D., Fyne, E., Shao, W., Spindler, J., Hattori, J., Anderson, E.M., Watters, S.A., Hill, S., Wu, X., Wells, D., Su, L., Luke, B.T., Halvas, E.K., Besson, G., Penrose, K.J., Yang, Z., Kwan, R.W., Van Waes, C., Uldrick, T., Citrin, D., Kovacs, J., Polis, M.A., Rehm, C.A., Gorelick, R., Piatak, M., Keele, B.F., Kearney, M.F., Coffin, J.M., Hughes, S.H., Mellors, J.W., and Maldarelli, F. (2016) Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo. Proc. Natl. Acad. Sci. USA 113: 1883-1888.     [Abstract]     [Full-text PDF (11,438 K) from publisher]
[PMID: 26858442]

Related Article:

Kim, M., and Siliciano, R.F. (2016) Commentary: Reservoir expansion by T-cell proliferation may be another barrier to curing HIV infection. Proc. Natl. Acad. Sci. USA 113: 1692-1694.

Maldarelli, F. (2016) The role of HIV integration in viral persistence: no more whistling past the proviral graveyard. J. Clin. Invest. 126: 438-447.     [Abstract]
[Full-text PDF (763 K) from publisher]     [PMID: 26829624]

Asher, I., Guri, K.M., Elbirt, D., Bezalel, S.R., Maldarelli, F., Mor, O., Grossman, Z., and Sthoeger, Z.M. (2016) Characteristics and outcome of patients diagnosed with HIV at older age. Medicine 95(1): e2327.
[Abstract]     [Full-text PDF (254 K) from publisher]     [PMID: 26735534]

Grossman, Z., Avidor, B., Mor, Z., Chowers, M., Levy, I., Shahar, E., Riesenberg, K., Sthoeger, Z., Maayan, S., Shao, W., Lorber, M., Olstein-Pops, K., Elbirt, D., Elinav, H., Asher, I., Averbuch, D., Istomin, V., Gottesman, B.S., Kedem, E., Girshengorn, S., Kra-Oz, Z., Shemer Avni, Y., Radian Sade, S., Turner, D., and Maldarelli, F. (2015) A population-structured HIV epidemic in Israel: Roles of risk and ethnicity. PLoS One 10(8): e0135061.
[Abstract]     [Full-text PDF (4884 K) from publisher]     [Supporting information]
[PMID: 26302493]

Bhardwaj, N., Maldarelli, F., Mellors, J., and Coffin, J.M. (2014) HIV-1 infection leads to increased transcription of HERV-K (HML-2) proviruses in vivo but not to increased virion production. J. Virol. 88: 11108-11120.     [Abstract]     [PMID: 25056891]
[Full-text PDF (2222 K) from publisher]     [Supplemental material (69 K)]

Maldarelli, F., Wu, X., Su, L., Simonetti, F.R., Shao, W., Hill, S., Spindler, J., Ferris, A.L., Mellors, J.W., Kearney, M.F., Coffin, J.M., and Hughes, S.H. (2014) Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 345: 179-183.
[Abstract]     [Full-text PDF (547 K) from publisher]     [Supplementary materials]
[PMID: 24968937]

Related Articles:

"News & Analysis" commentary in Science:
Cohen, J. (2014) Cancer genes help HIV persist, complicating cure efforts.
Science 343: 1188.

"Perspectives" commentary in Science:
Margolis, D., and Bushman, F. (2014) Persistence by proliferation? Science 345:
143-144.

ScienceNews feature about this paper:
Saey, T.H. (2014) HIV hides in growth-promoting genes. ScienceNews,
26 June 2014.

F1000Prime recommendation of this paper:
Damania, B. (2014) F1000Prime recommendation of [Maldarelli F et al.,
Science 2014, 345(6193):179-83]
. F1000Prime, 21 Jul 2014.

Cell "Leading Edge Select" feature about this paper:
Opening the HIV mystery box — The right spot to integrate and persist. Cell
158: 469, 471; 31 July 2014.

National Cancer Institute "In the Journals" summary of this paper:
HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells, July 2014.

National Cancer Institute press release about this paper:
NCI News Note — Where HIV genetic information is inserted into host DNA is linked
to clonal growth and persistence of infected cells
, 26 June 2014.

National Cancer Institute at Frederick Poster feature:
Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells, August 2014.

Editorial in Molecular Therapy:
Baum, C. (2014) Data vs. dogma: HIV-1 integrations driving clonal selection. Mol. Ther. 22: 1557-1558.

Shao, W., Kearney, M.F., Boltz, V.F., Spindler, J.E., Mellors, J.W., Maldarelli, F., and Coffin, J.M. (2014) PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data. J. Virol. Methods 203C: 73-80.     [Abstract]
[Full-text PDF (819 K) from publisher]     [PMID: 24681054]

Kearney, M.F., Spindler, J., Shao, W., Yu, S., Anderson, E.M., O'Shea, A., Rehm, C., Poethke, C., Kovacs, N., Mellors, J.W., Coffin, J.M., and Maldarelli, F. (2014) Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy. PLoS Pathog. 10(3): e1004010.     [Abstract]     [Full-text PDF (1253 K) from publisher]     [PMID: 24651464]

Klase, Z., Yedavalli, V.S., Houzet, L., Perkins, M., Maldarelli, F., Brenchley, J., Strebel, K., Liu, P., and Jeang, K.-T. (2014) Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA. PLoS Pathog. 10(3): e1003997.     [Abstract]
[Full-text PDF (3279 K) from publisher]     [PMID: 24651404]

Lau, C.Y., Maldarelli, F., Eckelman, W.C., and Neumann, R.D. (2014) Rational development of radiopharmaceuticals for HIV-1. Nucl. Med. Biol. 41: 299-308.     [Abstract]
[Full-text PDF (1305 K) from publisher]     [PMID: 24607432]

De Ravin, S.S., Gray, J.T., Throm, R.E., Spindler, J., Kearney, M., Wu, X., Coffin, J.M., Hughes, S.H., Malderelli, F., Sorrentino, B.P., and Malech, H.L. (2014) False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector. Mol. Ther. 22: 244-245.     [PubMed Citation]
[Full-text PDF (84 K) from publisher]     [PMID: 24487563]

Wiegand, A., and Maldarelli, F. (2014) Single-copy quantification of HIV-1 in clinical samples. In Human Retroviruses: Methods and Protocols (E. Vicenzi and G. Poli, eds.), Methods in Molecular Biology, Vol. 1087, Springer Science+Business Media, pp. 251-260.
[Abstract]     [PMID: 24158828]     [Full-text PDF (297 K) from publisher]

Sloan, E.A., Kearney, M.F., Gray, L.R., Anastos, K., Daar, E.S., Margolick, J., Maldarelli, F., Hammarskjold, M.L., and Rekosh, D. (2013) Limited nucleotide changes in the Rev response element during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization. J. Virol. 87: 11173-11186.     [Abstract]     [PMID: 23926352]
[Full-text PDF (2361 K) from publisher]     [Supplemental material (3723 K)]

Maldarelli, F., Kearney, M., Palmer, S., Stephens, R., Mican, J., Polis, M.A., Davey, R.T., Kovacs, J., Shao, W., Rock-Kress, D., Metcalf, J.A., Rehm, C., Greer, S.E., Lucey, D.L., Danley, K., Alter, H., Mellors, J.W., and Coffin, J.M. (2013) HIV populations are large and accumulate high genetic diversity in a nonlinear fashion. J. Virol. 87: 10313-10323.
[Abstract]     [PMID: 23678164; PMCID: PMC3754011]
[Full-text PDF (1909 K) from publisher]

Josefsson, L., Palmer, S., Faria, N.R., Lemey, P., Casazza, J., Ambrozak, D., Kearney, M., Shao, W., Kottilil, S., Sneller, M., Mellors, J., Coffin, J.M., and Maldarelli, F. (2013) Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4(+) T-cells contain one HIV-1 DNA molecule. PLoS Pathog. 9(6): e1003432.
[Abstract]     [Full-text PDF (536 K) from NIH Public Access]
[PMID: 23818847; PMCID: PMC3688524]

Andersson, E., Shao, W., Bontell, I., Cham, F., Cuong, D.D., Wondwossen, A., Morris, L., Hunt, G., Sönnerborg, A., Bertagnolio, S., Maldarelli, F., and Jordan, M.R. (2013) Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys. Infect. Genet. Evol. 18C: 125-131.
[Abstract]     [Full-text PDF (501K) from publisher]     [PMID: 23583545]

Casazza, J.P., Bowman, K.A., Adzaku, S., Smith, E.C., Enama, M.E., Bailer, R.T., Price, D.A., Gostick, E., Gordon, I.J., Ambrozak, D.R., Nason, M.C., Roederer, M., Andrews, C.A., Maldarelli, F.M., Wiegand, A., Kearney, M.F., Persaud, D., Ziemniak, C., Gottardo, R., Ledgerwood, J.E., Graham, B.S., Koup, R.A., and the VRC 101 Study Team. (2013) Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire. J. Infect. Dis. 207: 1829-1840.     [Abstract]     [PMID: 23482645]
[Full-text PDF (4301 K) from publisher]     [Supplementary data (2031 K)]

Wilson, E., Tanzosh, T., and Maldarelli, F. (2013) HIV diagnosis and testing: What every healthcare professional can do (and why they should). Oral Dis. 19: 431-439.     [Abstract]
[Full-text PDF (326 K) from publisher]     [PMID: 23347510]

Shao, W., Boltz, V.F., Spindler, J.E., Kearney, M.F., Maldarelli, F., Mellors, J.W., Stewart, C., Volfovsky, N., Levitsky, A., Stephens, R.M., and Coffin, J.M. (2013) Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of low-frequency drug resistance mutations in HIV-1 DNA. Retrovirology 10: 18.     [Abstract]
[Full-text PDF (1289 K) from NIH Public Access]     [PMID: 23402264; PMCID: PMC3599717]

Delviks-Frankenberry, K.A., Lengruber, R.B., Santos, A.F., Silveira, J.M., Soares, M.A., Kearney, M.F., Maldarelli, F., and Pathak, V.K. (2013) Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance. Virology 435: 433-441.     [Abstract]     [Full-text PDF (549 K) from publisher]
[PMID: 23068886; PMCID: PMC3534945]

Boltz, V.F., Ambrose, Z., Kearney, M.F., Shao, W., KewalRamani, V.N., Maldarelli, F., Mellors, J.W., and Coffin, J.M. (2012) Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase. J. Virol. 86: 12525-12530.     [Abstract]     [Full-text PDF article - 404 K]

Deeks, S.G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., Chomont, N., Chun, T.W., Churchill, M., Mascio, M.D., Katlama, C., Lafeuillade, A., Landay, A., Lederman, M., Lewin, S.R., Maldarelli, F., Margolis, D., Markowitz, M., Martinez-Picado, J., Mullins, J.I., Mellors, J., Moreno, S., O'Doherty, U., Palmer, S., Penicaud, M.C., Peterlin, M., Poli, G., Routy, J.P,, Rouzioux, C., Silvestri, G., Stevenson, M., Telenti, A., Lint, C.V., Verdin, E., Woolfrey, A., Zaia, J., and Barré-Sinoussi, F., for the International AIDS Society Scientific Working Group on HIV Cure. (2012) Towards an HIV cure: A global scientific strategy. Nat. Rev. Immunol. 12: 607-614.     [Abstract]     [Full-text PDF article - 400 K]

Ananworanich, J., Schuetz, A., Vandergeeten, C., Sereti, I., de Souza, M., Rerknimitr, R., Dewar, R., Marovich, M., van Griensven, F., Sekaly, R., Pinyakorn, S., Phanuphak, N., Trichavaroj, R., Rutvisuttinunt, W., Chomchey, N., Paris, R., Peel, S., Valcour, V., Maldarelli, F., Chomont, N., Michael, N., Phanuphak, P., Kim, J.H., on behalf of the RV254/SEARCH 010 Study Group. (2012) Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS ONE 7(3):e33948.
[Abstract]     [Full-text PDF article - 655 K]

Palmer, S., Boltz, V.F., Chow, J.Y., Martinson, N.A., McIntyre, J.A., Gray, G.E., Hopley, M.J., Mayers, D., Robinson, P., Hall, D.B., Maldarelli, F., Coffin, J.M., and Mellors, J.W., for the 1100.1413 Trial Investigators. (2012) Short-course combivir after single-dose nevirapine reduces but does not eliminate the emergence of nevirapine resistance in women. Antiviral Ther. 17: 327-336.     [Abstract]     [Full-text PDF article - 410 K]

Kearney, M.F., Spindler, J., Wiegand, A., Shao, W., Anderson, E.M., Maldarelli, F., Ruscetti, F.W., Mellors, J.W., Hughes, S.H., Le Grice, S.F.J., and Coffin, J.M. (2012) Multiple sources of contamination in samples from patients reported to have XMRV infection. PLoS ONE 7(2): e30889.     [Abstract]     [Full-text PDF article - 1911 K]

Besson, G.J., McMahon, D., Maldarelli, F., and Mellors, J.W. (2012) Short-course raltegravir intensification does not increase 2 long terminal repeat episomal HIV-1 DNA in patients on effective antiretroviral therapy. Clin. Infect. Dis. 54: 451-453.
[PubMed citation]     [Full-text PDF article - 66 K]

Kearney, M.F., Lee, K., Bagni, R.K., Wiegand, A., Spindler, J., Maldarelli, F., Pinto, P.A., Linehan, W.M., Vocke, C.D., Delviks-Frankenberry, K.A., deVere White, R.W., Del Prete, G.Q., Mellors, J.W., Lifson, J.D., KewalRamani, V.N., Pathak, V.K., Coffin, J.M., and Le Grice, S.F.J. (2011) Nucleic acid, antibody, and virus culture methods to detect xenotropic MLV-related virus in human blood samples. Adv. Virol. 2011: article ID 272193, 12 pages.
[Abstract]     [Full-text PDF article - 1428 K]

Cortez, K.J., and Maldarelli, F. (2011) Clinical management of HIV drug resistance. Viruses 3: 347-378.     [Abstract]     [Full-text PDF article - 687 K]

Dlamini, J.N., Hu, Z., Ledwaba, J., Morris, L., Maldarelli, F., Dewar, R.L., Highbarger, H.C., Somaroo, H., Sangweni, P., Follmann, D.A., and Pau, A.K. (2011) Genotypic resistance at viral rebound among patients who received lopinavir/ritonavir-based or efavirenz-based first antiretroviral therapy in South Africa. J. Acquir. Immune Defic. Syndr. 58: 304–308.
[Abstract]     [Full-text PDF article - 488 K]

Mens, H., Kearney, M., Wiegand, A., Spindler, J., Maldarelli, F., Mellors, J.W., and Coffin, J.M. (2011) Amplifying and quantifying HIV-1 RNA in HIV infected individuals with viral loads below the limit of detection by standard clinical assays. J. Vis. Exp. 55: e2960.
[Abstract]     [Full-text PDF article - 667 K]     [Video link]

Josefsson, L., King, M.S., Makitalo, B., Brannstrom, J., Shao, W., Maldarelli, F., Kearney, M., Hu, W.-S., Chen, J., Gaines, H., Mellors, J.W., Albert, J., Coffin, J.M., and Palmer, S.E. (2011) Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proc. Natl. Acad. Sci. USA 108: 11199-11204.
[Abstract]     [Full-text PDF article - 850 K]     [Supporting information - 77 K PDF]

Batorsky, R., Kearney, M.F., Palmer, S.E., Maldarelli, F., Rouzine, I.M., and Coffin, J.M. (2011) Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection. Proc. Natl. Acad. Sci. USA 108: 5661-5666.
[Abstract]     [Full-text PDF article - 494 K]

Boyd, S.D., Maldarelli, F., Sereti, I., Ouedraogo, G.L., Rehm, C.A., Boltz, V., Shoemaker, D., and Pau, A.K. (2011) Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient. Antiviral Ther. 16: 257-261.     [Abstract]     [Full-text PDF article - 192 K]

Ganesan, A., Crum-Cianflone, N., Higgins, J., Qin, J., Rehm, C., Metcalf, J., Brandt, C., Vita, J., Decker, C.F., Sklar, P., Bavaro, M., Tasker, S., Follmann, D., and Maldarelli, F. (2011) High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: Results of a double-blind randomized placebo controlled clinical trial. J. Infect. Dis. 203: 756-764.     [Abstract]     [Full-text PDF article - 192 K]

Catalfamo, M., Wilhelm, C., Tcheung, L., Proschan, M., Friesen, T., Park, J.H., Adelsberger, J., Baseler, M., Maldarelli, F., Davey, R., Roby, G., Rehm, C., and Lane, C. (2011) CD4 and CD8 T cell immune activation during chronic HIV infection: Roles of homeostasis, HIV, type I IFN, and IL-7. J. Immunol. 186: 2106-2116.
[Abstract]     [Full-text PDF article - 1398 K]     [Supplementary data - 311 K PDF]

Maldarelli, F. (2011) Targeting viral reservoirs: Ability of antiretroviral therapy to stop viral replication. Curr. Opin. HIV AIDS 6: 49-56.     [Abstract]     [Full-text PDF article - 249 K]

Kearney, M., Spindler, J., Shao, W., Maldarelli, F., Palmer, S., Hu, S.L., Lifson, J.D., KewalRamani, V.N., Mellors, J.W., Coffin, J.M., and Ambrose, Z. (2011) Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy. J. Virol. 85: 1067-1076.
[Abstract]     [Full-text PDF article - 1165 K]

Aloia, A.L., Sfanos, K.S., Isaacs, W.B., Zheng, Q., Maldarelli, F., De Marzo, A.M., and Rein, A. (2010) XMRV: A new virus in prostate cancer? Cancer Res. 70: 10028-10033.
[Abstract]     [Full-text PDF article - 930 K]     [Supplementary data - 282 K]

Kutty, G., Achaz, G., Maldarelli, F., Varma, A., Shroff, R., Becker, S., Fantoni, G., and Kovacs, J.A. (2010) Characterization of the meiosis-specific recombinase Dmc1 of Pneumocystis. J. Infect. Dis. 202: 1920-1929.     [Abstract]     [Full-text PDF article - 814 K]

Mens, H., Kearney, M., Wiegand, A., Shao, W., Schřnning, K., Gerstoft, J., Obel, N., Maldarelli, F., Mellors, J.W., Benfield, T., and Coffin, J.M. (2010) HIV-1 continues to replicate and evolve in patients with natural control of HIV infection. J. Virol. 84: 12971-12981.
[Abstract]     [Full-text PDF article - 840 K]

Related Article:

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Kearney, M., and Maldarelli, F. (2010) Editorial commentary: Current status of xenotropic murine leukemia virus-related retrovirus in chronic fatigue syndrome and prostate cancer: Reach for a scorecard, not a prescription pad. J. Infect. Dis. 202: 1463-1466.
[Abstract]     [Full-text PDF article - 174 K]

Jordan, M.R., Kearney, M., Palmer, S., Shao, W., Maldarelli, F., Coakley, E.P., Chappey, C., Wanke, C., and Coffin, J.M. (2010) Comparison of standard PCR/cloning to single genome sequencing for analysis of HIV-1 populations. J. Virol. Methods 168: 114-120.
[Abstract]     [Full-text PDF article - 208 K]

Galli, A., Kearney, M., Nikolaitchik, O.A., Yu, S., Chin, M.P.S., Maldarelli, F., Coffin, J.M., Pathak, V.K., and Hu, W.-S. (2010) Patterns of human immunodeficiency virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication. J. Virol. 84: 7651-7661.
[Abstract]     [Full-text PDF article - 676 K]

Boltz, V.F., Maldarelli, F., Martinson, N., Morris, L., McIntyre, J.A., Gray, G., Hopley, M.J., Kimura, T., Mayers, D.L., Robinson, P., Mellors, J.W., Coffin, J.M., and Palmer, S.E. (2010) Optimization of allele-specific PCR using patient-specific HIV consensus sequences for primer design. J. Virol. Methods 164: 122-126.
[Abstract]     [Full-text PDF article - 651 K]

McMahon, D., Jones, J., Wiegand, A., Gange, S.J., Kearney, M., Palmer, S., McNulty, S., Metcalf, J.A., Acosta, E., Rehm, C., Coffin, J.M., Mellors, J.W., and Maldarelli, F. (2010) Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin. Infect. Dis. 50: 912-919.     [Abstract]     [Full-text PDF article - 392 K]

Shao, W., Kearney, M., Maldarelli, F., Mellors, J.W., Stephens, R.M., Lifson, J.D., KewalRamani, V.N., Ambrose, Z., Coffin, J.M., and Palmer, S.E. (2009) RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy. Retrovirology 6: 101.
[Abstract]     [Full-text PDF article - 1832 K]

Delviks-Frankenberry, K.A., Nikolenko, G.N., Maldarelli, F., Hase, S., Takebe, Y., and Pathak, V.K. (2009) Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine. J. Virol. 83: 8502-8513.
[Abstract]     [Full-text PDF article - 1260 K]

Dinoso, J.B., Kim, S.Y., Wiegand, A.M., Palmer, S.E., Gange, S.J., Cranmer, L., O'Shea, A., Callender, M., Spivak, A., Brennan, T., Kearney, M.F., Proschan, M.A., Mican, J.M., Rehm, C.A., Coffin, J.M., Mellors, J.W., Siliciano, R.F., and Maldarelli, F. (2009) Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 106: 9403-9408.
[Abstract]     [Full-text PDF article - 987 K]
[PNAS online supporting information related to this article - 176 K PDF]

Morse, C., and Maldarelli, F. (2009) Acquired immunodeficiency syndrome (AIDS). In Strober, W., and Gottesman, S. (eds.), Immunology: Clinical Case Studies and Disease Pathophysiology, Wiley-Blackwell.

Nies-Kraske, E., Schacker, T.W., Condoluci, D., Orenstein, J., Brenchley, J., Fox, C., Daucher, M., Dewar, R., Urban, E., Hill, B., Guenaga, J., Hoover, S., Maldarelli, F., Hallahan, C.W., Horn, J., Kottilil, S., Chun, T.W., Folino, M., Palmer, S., Wiegand, A., O'Shea, M.A., Metcalf, J.A., Douek, D.C., Coffin, J., Haase, A., Fauci, A.S., and Dybul, M. (2009) Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy. J. Infect. Dis. 199: 1648-1656.     [Abstract]     [Full-text PDF article - 523 K]

Wilkin, T.J., McKinnon, J.E., Dirienzo, A.G., Mollan, K., Fletcher, C.V., Margolis, D.M., Bastow, B., Thal, G., Woodward, W., Godfrey, C., Wiegand, A., Maldarelli, F., Palmer, S., Coffin, J.M., Mellors, J.W., and Swindells, S. (2009) Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: Final 48-week clinical and virologic outcomes. J. Infect. Dis. 199: 866-871.
[Abstract]     [Full-text PDF article - 79 K]

Kearney, M., Maldarelli, F., Shao, W., Margolick, J.B., Daar, E.S., Mellors, J.W., Rao, V., Coffin, J.M., and Palmer, S. (2009) Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals. J. Virol. 83: 2715-2727.
[Abstract]     [Full-text PDF article - 3286 K]

Robertson, S.M., Maldarelli, F., Natarajan, V., Formentini, E., Alfaro, R.M., and Penzak, S.R. (2009) Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects. J. Acquir. Immune Defic. Syndr. 49: 513-519.
[Abstract]     [Full-text PDF article - 128 K]

Porter, B.O., Anthony, K.B., Shen, J., Hahn, B., Keh, C.E., Maldarelli, F., Blackwelder, W.C., Lane, H.C., Kovacs, J.A., Davey, R.T., and Sereti, I. (2009) Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: A randomized controlled trial. AIDS 23: 203-212.     [Abstract]     [Full-text PDF article - 252 K]

Migueles, S.A., Osborne, C.M., Royce, C., Compton, A.A., Joshi, R.P., Weeks, K.A., Rood, J.E., Berkley, A.M., Sacha ,J.B., Cogliano-Shutta, N.A., Lloyd, M., Roby, G., Kwan, R., McLaughlin, M., Stallings, S., Rehm, C., O'Shea, M.A., Mican, J., Packard, B.Z., Komoriya, A., Palmer, S., Wiegand, A.P., Maldarelli, F., Coffin, J.M., Mellors, J.W., Hallahan, C.W., Follman, D.A., and Connors, M. (2008) Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29: 1009-1021.
[Abstract]     [Full-text PDF article - 1649 K]

Ramanathan, R., Pau, A.K., Busse, K.H., Zemskova, M., Nieman, L., Kwan, R., Hammer, J.H., Mican, J.M., and Maldarelli, F. (2008) Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir. Clin. Infect. Dis. 47: e97-99.     [Abstract]     [Full-text PDF article - 109 K]

Kutty, G., Maldarelli, F., Achaz, G., and Kovacs, J.A. (2008) Variation in the major surface glycoprotein genes in Pneumocystis jirovecii. J. Infect. Dis. 198: 741-749.
[Abstract]     [Full-text PDF article - 523 K]

Palmer, S., Maldarelli, F., Wiegand, A., Bernstein, B., Hanna, G.J., Brun, S.C., Kempf, D.J., Mellors, J.W., Coffin, J.M., and King, M.S. (2008) Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc. Natl. Acad. Sci. USA 105: 3879-3884.     [Abstract]     [Full-text PDF article]

Kearney, M., Palmer, S., Maldarelli, F., Shao, W., Polis, M.A., Mican, J., Rock-Kress, D., Margolick, J.B., Coffin, J.M., and Mellors, J.W. (2008) Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase. AIDS 22: 497-501.
[Abstract]     [Full-text PDF article]

Ambrose, Z., Palmer, S., Boltz, V.F., Kearney, M., Larsen, K., Polacino, P., Flanary, L., Oswald, K., Piatak, M., Jr., Smedley, J., Shao, W., Bischofberger, N., Maldarelli, F., Kimata, J.T., Mellors, J.W., Hu, S.-L., Coffin, J.M., Lifson, J.D., and KewalRamani, V.N. (2007) Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy. J. Virol. 81: 12145-12155.
[Abstract]     [Full-text PDF article]

Maldarelli, F., Palmer, S., King, M.S., Wiegand, A., Polis, M.A., Mican, J., Kovacs, J.A., Davey, R.T., Rock-Kress, D., Dewar, R., Liu, S., Metcalf, J.A., Rehm, C., Brun, S.C., Hanna, G.J., Kempf, D.J., Coffin, J.M., and Mellors, J.W. (2007) ART suppresses plasma HIV- 1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog. 3: e46.
[Abstract]     [Full-text PDF article]

Morse, C., and Maldarelli, F. (2007) Enfuvirtide antiviral activity despite rebound viremia and resistance mutations: Fitness tampering or a case of persistent braking on entering? (Editorial Commentary). J. Infect. Dis. 195:318-321.     [PubMed citation]     [Full-text PDF article]

Nikolenko, G.N., Delviks-Frankenberry, K.A., Palmer, S., Maldarelli, F., Fivash, M.J., Jr., Coffin, J.M., and Pathak, V.K. (2007) Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance. Proc. Natl. Acad. Sci. USA 104: 317-322.      [Abstract]     [Full-text PDF article]

Gafni, R.I., Hazra, R., Reynolds, J.C., Maldarelli, F., Tullio, A.N., DeCarlo, E., Worrell, C.J., Flaherty, J., Yale, K., Kearney, B.P., and Zeichner, S.L. (2006) Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: Impact on bone mineral density in HIV-infected children. Pediatrics 118: 711-718.
[Abstract]     [Full-text PDF article]

Bashirova, A.A., Bleiber, G., Qi, Y., Hutcheson, H., Yamashita, T., Johnson, R.C., Cheng, J., Alter, G., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., May, M., Maldarelli, F., Jacobson, L., O'Brien, S.J., Telenti, A., and Carrington, M. (2006) Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1. J. Virol. 80: 6757-6763.     [Abstract]     [Full-text PDF article]

Palmer, S., Boltz, V., Martinson, N., Maldarelli, F., Gray, G., McIntyre, J., Mellors, J., Morris, L., and Coffin, J. (2006) Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission. Proc. Natl. Acad. Sci. USA 103: 7094-7099.     [Abstract]     [Full-text PDF article]

Palmer, S., Boltz, V., Maldarelli, F., Kearney, M., Halvas, E.K., Rock, D., Falloon, J., Davey, R.T., Jr., Dewar, R.L., Metcalf, J.A., Mellors, J.W., and Coffin, J.M. (2006) Selection and persistence of non-nucleoside reverse transcriptase inhibitor-resistant HIV-1 in patients starting and stopping non-nucleoside therapy. AIDS 20: 701-710.
[Abstract]     [Full-text PDF article]


Last modified: 19 July 2019


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