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Office of the Director, HIV Dynamics and Replication Program

Eric O. Freed, Ph.D., Director

Stephen Oroszlan, Ph.D., Scientist Emeritus


Retroviral Replication Laboratory

Stephen H. Hughes, Ph.D., Chief, Retroviral Replication Laboratory; Head, Vector Design and Replication Section

  • HIV reverse transcription and integration
  • Inhibitors of HIV reverse transcription and integration
  • Resistance to anti-RT and anti-IN drugs
  • HIV integration sites in cultured cells and in patients

Alex Compton, Ph.D., Head, Antiviral Immunity and Resistance Section

  • Antiviral innate immunity
  • Host-pathogen coevolution
  • Emerging viruses
  • Gene therapy

Eric O. Freed, Ph.D., Head, Virus-Cell Interaction Section

  • Inhibitors of HIV maturation
  • HIV assembly and release and envelope glycoprotein incorporation
  • Interactions between viral and cellular proteins
  • Trafficking of retroviral proteins

Wei-Shau Hu, Ph.D., Head, Viral Recombination Section

  • RNA packaging and virus assembly
  • HIV RNA trafficking
  • Mechanisms of reverse transcription and recombination
  • HIV replication

Vinay K. Pathak, Ph.D., Head, Viral Mutation Section

  • Structure and function of APOBEC3 (A3) proteins
  • Host factors that facilitate Vif-mediated degradation of A3 proteins
  • Elucidation of early stage of HIV replication by tracking A3F-labeled viral complexes in infected cells

Alan Rein, Ph.D., Head, Retrovirus Assembly Section

  • Molecular mechanisms of retroviral assembly and replication
  • Interactions of retroviral proteins with nucleic acids
  • Interactions of retroviral components with host antiviral factors


Host-Virus Interaction Branch

Stephen H. Hughes, Ph.D., Acting Chief, Host-Virus Interaction Branch

Frank Maldarelli, M.D., Ph.D., Head, Clinical Retrovirology Section

  • Studies of HIV population genetics in vivo
  • Studies of HIV persistence during combination antiretroviral therapy in vivo
  • Clinical interventional studies of HIV reservoirs
  • Clinical studies of HIV resistance

Mary Kearney, Ph.D., Head, Translational Research Unit

  • Development of novel ultrasensitive HIV assays
  • Dynamics of HIV genetic diversity and expression
  • Mechanisms for rebound from the HIV reservoir
  • Persistent viremia in patients on and off antiretroviral therapy


CONSULTANTS:

John M. Coffin, Ph.D., American Cancer Society Research Professor, Tufts University, and Special Advisor to Director, Center for Cancer Research, National Cancer Institute

John W. Mellors, M.D., Chief, Division of Infectious Diseases, University of Pittsburgh, and Director, HIV/AIDS Program, University of Pittsburgh Medical Center



Last modified: 11 April 2017

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